Abstract
A novel polycationic analogue of gratisin, cyclo(-Val-Orn-Leu-D-Phe-Pro-D-Lys-)2, was designed and synthesized, which exhibited strong activity against all Gram-positive and Gram-negative bacteria tested. Its activity against Pseudomonas aeruginosa IFO 3080 was two times higher than gramicidin S.
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Tamaki, M., Kokuno, M., Suzuki, Y. et al. A Novel Polycationic Analogue of Gratisin with Antibiotic Activity against both Gram-positive and Gram-negative Bacteria. J Antibiot 61, 33–35 (2008). https://doi.org/10.1038/ja.2008.106
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DOI: https://doi.org/10.1038/ja.2008.106