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Body mass index growth trajectories associated with the different parameters of the metabolic syndrome at adulthood

International Journal of Obesity volume 41, pages 1518–1525 (2017)Cite this article

Subjects

Abstract

Background:

Growth trajectories have shown to be related to obesity and metabolic risks in later life, however body mass index (BMI) trajectories according to the presence or absence of metabolic syndrome (MS) and its parameters in adulthood are scarce in literature.

Objectives:

To investigate BMI trajectories during childhood in relation to MS and its parameters in adult age.

Methods:

A total of 1919 subjects (43.4% male, 20–60 y) participated in this retrospective cohort study. Height, weight, waist circumference (WC), blood glucose, high-density lipoprotein cholesterol, triglycerides and blood pressure were measured at adulthood. Childhood weight and height were collected retrospectively from health booklets. Differences between BMI growth curves of subjects with and without MS were assessed using mixed models for correlated data.

Results:

BMI trajectories differed according to the presence or not of MS at adulthood, from the age of 4 years forward (all P<0.05), to the presence or not of hypertriglyceridemia from 1.5 years forward (all P<0.05), and to WC>94 cm (men) / 80 cm (women) compared to lower WC, at all ages (all P<0.05).

Conclusions:

BMI growth curves differ according to the presence or not of MS at adulthood, but differences only appeared after the age of 4 years. Changes vary according to the MS parameters considered. Deviation of the MS-associated BMI curve from normal pattern could correspond to alteration in body composition. These differences in BMI trajectories during childhood support the theory of an early origin of the MS, justifying early prevention.

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Acknowledgements

We are indebted to the participants for their involvement in the study. We thank Véronique Gourlet for data management and statistical analyses.

Author contributions

KVG supervised statistical analyses, interpreted data and drafted the manuscript. M-FR-C designed the protocol, interpreted the data and critically revised the manuscript. GG, DG and OL collected the data and critically revised the manuscript. SH designed the protocol and critically revised the manuscript. SP designed the protocol, supervised statistical analyses, interpreted data and critically revised the manuscript.

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Authors and Affiliations

  1. Paris 13 University, Nutritional Epidemiology Research Team, French National Institute of Health and Medical Research (Inserm) U1153, French National Institute for Agricultural Research (Inra) U1125, French National Conservatory of Arts and Crafts (CNAM), Sorbonne Paris Cité University, Bobigny, France

    K V Giudici, M-F Rolland-Cachera, S Hercberg & S Péneau

  2. Institut inter-Régional pour la Santé (IRSA), La Riche, France

    G Gusto, D Goxe & O Lantieri

  3. Université Paris 13, Sorbonne Paris Cité, USEN (Unité de surveillance et d’épidémiologie nutritionnelle), Institut de Veille Sanitaire (InVS), Bobigny,, France

    S Hercberg

  4. Département de Santé Publique, Hôpital Avicenne, Bobigny, France

    S Hercberg

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  1. K V Giudici
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Correspondence to S Péneau.

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Giudici, K., Rolland-Cachera, MF., Gusto, G. et al. Body mass index growth trajectories associated with the different parameters of the metabolic syndrome at adulthood. Int J Obes 41, 1518–1525 (2017). https://doi.org/10.1038/ijo.2017.119

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