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Obesity-related immune responses and their impact on surgical outcomes

International Journal of Obesity volume 39, pages 877–883 (2015)Cite this article

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Abstract

The obesity epidemic represents a critical disease burden with broad clinical consequences. At the same time, obesity has been linked to inferior surgical outcomes and considered a contraindication for some elective surgical procedures. A growing body of mechanistic evidence has accumulated linking obesity to changes of metabolism and immune responses. This concept provides an integrated inflammatory network based on the perception of obesity as a state of chronic low-grade inflammation. With a more detailed understanding of this dynamic network and mechanistic insights, novel treatment and management strategies may be developed with the goal to optimize surgical outcomes in obese patients.

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Acknowledgements

This work has been supported in part by a grant from the IFB Integrated Research and Treatment Center Adiposity Diseases (to MQ), the NIH (RO-1 AG039449) and the Instituto Carlos Slim de la Salud (both to SGT).

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Authors and Affiliations

  1. Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    M Quante, A ElKhal & S G Tullius

  2. IFB Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany

    M Quante & A Dietrich

  3. Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany

    M Quante & A Dietrich

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  1. M Quante
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Correspondence to S G Tullius.

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Quante, M., Dietrich, A., ElKhal, A. et al. Obesity-related immune responses and their impact on surgical outcomes. Int J Obes 39, 877–883 (2015). https://doi.org/10.1038/ijo.2015.21

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