Abstract
Background:
Obesity is the result of chronic positive energy balance. The mechanisms underlying the regulation of energy homeostasis and food intake are not understood. Despite large increases in fat mass (FM), recent evidence indicates that fat-free mass (FFM) rather than FM is positively associated with intake in humans.
Methods:
In 184 humans (73 females/111 males; age 34.5±8.8 years; percentage body fat: 31.6±8.1%), we investigated the relationship of FFM index (FFMI, kg m−2), FM index (FMI, kg m−2); and 24-h energy expenditure (EE, n=127) with ad-libitum food intake using a 3-day vending machine paradigm. Mean daily calories (CAL) and macronutrient intake (PRO, CHO, FAT) were determined and used to calculate the relative caloric contribution of each (%PRO, %CHO, %FAT) and percent of caloric intake over weight maintaining energy needs (%WMENs).
Results:
FFMI was positively associated with CAL (P<0.0001), PRO (P=0.0001), CHO (P=0.0075) and FAT (P<0.0001). This remained significant after adjusting for FMI. Total EE predicted CAL and macronutrient intake (all P<0.0001). FMI was positively associated with CAL (P=0.019), PRO (P=0.025) and FAT (P=0.0008). In models with both FFMI and FMI, FMI was negatively associated with CAL (P=0.019) and PRO (P=0.033). Both FFMI and FMI were negatively associated with %CHO and positively associated with %FAT (all P<0.001). EE and FFMI (adjusted for FMI) were positively (EE P=0.0085; FFMI P=0.0018) and FMI negatively (P=0.0018; adjusted for FFMI) associated with %WMEN.
Conclusion:
Food and macronutrient intake are predicted by FFMI and to a lesser degree by FMI. FFM and FM may have opposing effects on energy homeostasis.
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References
Ogden C, Carroll M, Kit B, Flegal K Prevalence of obesity in the United States, 2009-2010. NCHS Data Brief 2012; 82: 1–8.
Finkelstein E, Trogden J, Cohen J, Dietz W . Annual medical spending attributable to obesity: payer- and service-specific estimates. Health Aff 2009; 28: w822–w831.
Flegal K, Carroll M, Ogden C, Johnson C . Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002; 288: 1723–1727.
Flegal K, Carroll M, Ogden C, Curtin L . Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010; 303: 235–241.
Gustafson D, Rotherberg E, Blennow K, Steen B, Skoog I . An 18-year follow-up of overweight and risk of Alzheimer disease. Arch Intern Med 2003; 163: 1524–1528.
Hu G, Jousilahti P, Nissinen A, Antikainen R, Kivipelto M, Tuomilehto J . Body mass index and the risk of Parkinson disease. Neurology 2006; 67: 1955–1959.
Dagogo-Jack S, Fanelli C, Paramore D, Brothers J, Landt M . Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 1996; 45: 695–698.
Gautron L, Elmquist J . Sixteen years and counting: an update on leptin in energy balance. J Clin Invest 2011; 121: 2087–2093.
Berthoud H, Morrison C . The brain, appetite, and obesity. Ann Rev Psychol 2008; 59: 55–92.
Ravussin E, Lillioja S, Anderson T, Christin L, Bogardus C . Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. J Clin Invest 1986; 78: 1568–1578.
Ravussin E, Burnand B, Schutz Y, Jequier E . Twenty-four-hour energy expenditure and resting metabolic rate in obese, moderately obese, and control subjects. Am J Clin Nutr 1982; 35: 566–573.
Blundell J, Caudwell P, Gibbons C, Hopkinds M, Naslund E, King N et al. Body composition and appetite: fat-free mass (but not fat mass or BMI) is positively associated with self-determined meal size and daily energy intake in humans. Br J Nutr 2012; 107: 445–449.
Caudwell P, Finlayson G, Gibbons C, Hopkins M, King N, Naslund E et al. Resting metabolic rate is associated with hunger, self-determined meal size, and daily energy intake and may represent a marker for appetite. Am J Clin Nutr 2013; 37: 7–14.
Venti C, Votruba S, Franks P, Krakoff J, Salbe A . Reproducibility of ad libitum energy intake with the use of a computerized vending machine system. Am J Clin Nutr 2010; 91/2: 343–348.
Ferraro R, Boyce VL, Swinburn B, De Gregorio M, Ravussin E . Energy cost of physical activity on a metabolic ward in relationship to obesity. Am J Clin Nutr 1991; 53/6: 1368–1371.
VanItallie T, Yang M, Heymsfield S, Funk R, Boileau R . Height-normalized indices of the body’s fat-free mass and fat mass: potentially useful indicators of nutritional status. Am J Clin Nutr 1990; 52: 953–959.
Votruba S, Kirchner H, Tschop M, Salbe A, Krakoff J . Morning ghrelin concentrations are not affected by short-term overfeeding and do not predict ad libitum food intake in humans. Am J Clin Nutr 2009; 89: 801–806.
Millward D . Metabolic demands for amino acids and the human dietary requirement: Millward and Rivers (1988) revisited. J Nutr 1998; 128(Suppl): S2563–S2576.
Linde J, Utter J, Jeffrey R, Sherwood N, Pronk N, Boyle R et al. Specific food intake, fat and fiber intake, and behavioral correlates of BMI among overweight and obese members of a managed care organization. Int J Behavior Nutr Physical Act 2006; 3: 42.
Rissanen A, Hakala P, Lissner L, Mattlar C-E, Koskenvuo M, Ronnemaa T . Acquired preference especially for dietary fat and obesity: a study of weight-discordant monozygotic twin pairs. Int J Obes 2002; 26: 973–977.
Ahima R, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382: 250–252.
Chan J, Heist K, DePaoli A, Veldhuis J, Mantzoros C . The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest 2003; 111: 1409–1421.
Tang-Christensen M, Havel P, Jacobs R, Larsen P, Cameron J . Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques. J Clin Endocrinol Metab 1999; 84: 711–717.
Heymsfield S, Greenberg A, Fujioka K, Dixon R, Kushner R, Hunt T et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999; 282: 1568–1575.
Henry B, Clarke I . Adipose tissue hormones and the regulation of food intake. J Neuroendocrinol 2008; 20: 842–849.
Pedersen B, Febbraio M . Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 2012; 8: 457–465.
Ropelle E, Flores M, Cintra D, Rocha G, Pauli J, Morari J et al. IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKK? and ER stress inhibition. PLoS Biol 2010; 8: 8.
Weise C, Thiyyagura P, Reiman E, Krakoff J . Fat-free body mass but not fat mass is associated with reduced gray matter volume of cortical brain regions implicated in autonomic and homeostatic regulation. Neuroimage 2013; 64: 712–721.
Jumpertz R, Venti C, Le D, Michaels J, Parrington S, Krakoff J et al. Food label accuracy of common snack foods. Obesity 2013; 21: 164–169.
Acknowledgements
This research was supported by the Intramural Research Program of the NIH, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
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Weise, C., Hohenadel, M., Krakoff, J. et al. Body composition and energy expenditure predict ad-libitum food and macronutrient intake in humans. Int J Obes 38, 243–251 (2014). https://doi.org/10.1038/ijo.2013.85
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DOI: https://doi.org/10.1038/ijo.2013.85
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