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Hypovolaemia-induced mild hypoxia produces subchronic metabolic dysfunction

International Journal of Obesity volume 33, page 605 (2009)Cite this article

In the recent review by Ye published in this journal, the emerging role of adipose tissue hypoxia is discussed with respect to obesity and insulin resistance.1 This is a timely review as it would appear that tissue hypoxia may not just be confined to adipose tissue but may well be a problem, or rather perhaps the cause, of a number of diseases that might have a common aetiology, such as obesity, diabetes and perhaps even cancer and hypertension.

It has been observed that obese patients have tissue hypoxia thus making it more difficult to operate with an increased risk of wound infection.2 Others have observed that increased perioperative fluid administration increases significantly tissue perfusion and oxygen partial pressure in normal weight patients3 and thus aids healing. This would suggest that there could be a link between hypovolaemia and tissue hypoxia and that in obese patients this hypovolaemia is more aggravated. Hypovolaemia-induced angiotensin release has been implicated in obesity through its capacity to decrease membrane glucose transport and insulin sensitivity as giving antagonists of the AT1 angiotensin-specific receptor decreases insulin resistance.4 Decreased glucose availability would imply dysfunction of cell metabolism through disruption of mitochondrial activity, which may be a common denominator of obesity and other elements of the metabolic syndrome, such as diabetes and hypertension.

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References

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  1. Université Henri Poincaré, U 961 UHP-INSERM, Risque cardiovasculaire, rigiditi-fibrose et hypercoagulabiliti Bbt. D, ler itage, Faculti de Midecine, B.P. 184-54505 VAND UVRE Les Nancy, Cedex, France. E-mail: simon.thornton@nancy.inserm.fr,

    S N Thornton

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Thornton, S. Hypovolaemia-induced mild hypoxia produces subchronic metabolic dysfunction. Int J Obes 33, 605 (2009). https://doi.org/10.1038/ijo.2009.26

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