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Obesity and aging have divergent genomic fingerprints

International Journal of Obesity volume 32, pages 1873–1874 (2008)Cite this article

Abstract

Aging is associated with increased visceral fat, and recent studies suggested that in turn, visceral fat could influence longevity. We therefore tested whether obesity could be a condition of premature aging. Whole-genome microarray analysis of gene expression between obese mice, aged mice and their respective controls, revealed that long-term adaptations in gene expression in visceral fat upon aging are different from those occurring during fat accretion in young adult animals, suggesting specific, divergent and non overlapping pathways of regulation.

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Acknowledgements

We thank Dr Yves Deshaies for critical reading of the paper. This work was supported by FER/CRHL studentships to SM, a CIHR New Investigator Award to FP (SIC-70851) and operating grants from CIHR (MOP-66967) and NSERC (311910) to FP.

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Authors and Affiliations

  1. Laval Hospital Research Center and Faculty of Pharmacy, Laval University, Québec, QC, Canada

    S Miard & F Picard

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  1. S Miard
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  2. F Picard
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Correspondence to F Picard.

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Supplementary Information accompanies the paper on International Journal of Obesity website (http://www.nature.com/ijo)

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Miard, S., Picard, F. Obesity and aging have divergent genomic fingerprints. Int J Obes 32, 1873–1874 (2008). https://doi.org/10.1038/ijo.2008.214

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  • DOI: https://doi.org/10.1038/ijo.2008.214

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