Abstract
Sleep-disordered breathing (SDB) is a recognized risk factor for excessive daytime sleepiness (EDS) and hypertension, but evidence of this association in Asian women is limited. We conducted a cross-sectional study of 3,568 women aged 30–69 years living in three Japanese communities. The 3% oxygen desaturation index (ODI) was selected as the indicator of SDB, and blood oxygen fall was estimated by overnight pulse oximetry. The prevalence of SDB was 20.2% for 3% ODI ≥5, 6.4% for 3% ODI ≥10, and 2.8% for 3% ODI ≥15 among Japanese women aged 30–69 years. The 3% ODI was positively associated with the prevalence of self-reported EDS and mean values of systolic and diastolic blood pressure levels. The multivariate odds ratios for 3% ODI of 5–9, 10–14, and ≥15 in reference to 3% ODI <5 were 1.9 (1.2–3.0), 2.2 (1.0–4.6), and 1.8 (0.7–4.4) (p for trend =0.01), respectively, for EDS and 1.1 (0.9–1.4), 1.2 (0.8–1.8), and 2.2 (1.4–3.4) (p for trend <0.001), respectively, for hypertension. The severity of SDB was significantly associated with EDS and hypertension among Japanese women.
Similar content being viewed by others
Article PDF
References
Young T, Peppard P, Palta M, et al: Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med 1997; 157: 1746–1752.
Nieto FJ, Young TB, Lind BK, et al: Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 2000; 283: 1829–1836.
Bixler EO, Vgontzas AN, Lin HM, et al: Association of hypertension and sleep-disordered breathing. Arch Intern Med 2000; 160: 2289–2295.
Duran J, Esnaola S, Rubio R, Iztueta A : Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. Am J Respir Crit Care Med 2001; 163: 685–689.
Peppard PE, Young T, Palta M, Skatrud J : Prospective study of the association between sleep disordered breathing and hypertension. N Engl J Med 2000; 342: 1378–1384.
Newman AB, Nieto FJ, Guidry U, et al, Sleep Heart Health Study Research Group: Relation of sleep-disordered breathing to cardiovascular disease risk factors: the Sleep Heart Health Study. Am J Epidemiol 2001; 154: 50–59.
Jean-Louis G, Zizi F, Casimir G, DiPalma J, Mukherji R : Sleep-disordered breathing and hypertension among African Americans. J Hum Hypertens 2005; 19: 485–490.
Sasanabe R, Banno K, Otake K, et al: Metabolic syndrome in Japanese patients with obstructive sleep apnea syndrome. Hypertens Res 2006; 29: 315–322.
Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V : Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 2005; 353: 2034–2041.
Cadilhac DA, Thorpe RD, Pearce DC, et al, SCOPES II Study Group: Sleep disordered breathing in chronic stroke survivors. A study of the long term follow-up of the SCOPES cohort using home based polysomnography. J Clin Neurosci 2005; 12: 632–637.
Peker Y, Hedner J, Norum J, Kraiczi H, Carlson J : Increased incidence of cardiovascular disease in middle-aged men with obstructive sleep apnea: a 7-year follow-up. Am J Respir Crit Care Med 2002; 166: 159–165.
Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S : The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993; 328: 1230–1235.
Kim J, In K, Kim J, et al: Prevalence of sleep-disordered breathing in middle-aged Korean men and women. Am J Respir Crit Care Med 2004; 170: 1108–1113.
Ip MS, Lam B, Tang LC, Lauder IJ, Ip TY, Lam WK : A community study of sleep-disordered breathing in middle-aged Chinese women in Hong Kong: prevalence and gender differences. Chest 2004; 125: 127–134.
Cui R, Tanigawa T, Sakurai S, Yamagishi K, Iso H : Relationships between sleep-disordered breathing and blood pressure and excessive daytime sleepiness among truck drivers. Hypertens Res 2006; 29: 605–610.
Tanigawa T, Tachibana N, Yamagishi K, et al: Relationship between sleep-disordered breathing and blood pressure levels in community-based samples of Japanese men. Hypertens Res 2004; 27: 479–484.
Tanigawa T, Muraki I, Umesawa M, et al: Sleep-disordered breathing and blood pressure levels among shift and day workers. Am J Hypertens 2006; 19: 346–351.
Shimamoto T, Komachi Y, Inada H, et al: Trends for coronary heart disease and stroke and their risk factors in Japan. Circulation 1989; 79: 503–515.
Shimamoto T, Iso H, Tanigawa T, et al: Stroke, ischemic heart disease and their risk factors in Kyowa town, Ibaraki, Japan. Cardioangiology 2000; 48: 127–133 ( in Japanese).
Kitamura A, Sato S, Naito Y, et al: Trends in the incidence of cardiovascular diseases and risk factors among urban and rural Japanese males. Nippon Koshu Eisei Zasshi 2001; 48: 378–394 ( in Japanese).
Yamagishi K, Iso H, Kitamura A : Smoking raises the risk of total and ischemic strokes in hypertension men. Hypertens Res 2003; 26: 209–217.
Cui R, Iso H, Yamagishi K, et al: Ankle-arm blood pressure index and cardiovascular risk factors in elderly Japanese men. Hypertens Res 2003; 26: 377–382.
Nakamata M, Kubota Y, Sakai K, et al: The limitation of screening test for patients with sleep apnea syndrome using pulse oximetry. J Jpn Soc Respir Care 2003; 12: 401–406 ( in Japanese).
Ferguson KA, Ono T, Lowe AA, Ryan CF, Fleetham JA : The relationship between obesity and craniofacial structure in obstructive sleep apnea. Chest 1995; 108: 375–381.
Gottlieb DJ, Whitney CW, Bonekat WH, et al: Relation of sleepiness to respiratory disturbance index: the Sleep Heart Health Study. Am J Respir Crit Care Med 1999; 159: 502–507.
Brooks D, Horner RL, Kozar LF, Render-Teixeira CL, Phillipson EA : Obstructive sleep apnea as a cause of systemic hypertension. Evidence from a canine model. J Clin Invest 1997; 99: 106–109.
Becker HF, Jerrentrup A, Ploch T, et al: Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation 2003; 107: 68–73.
Somers VK, Dyken ME, Clary MP, Abboud FM : Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 1995; 96: 1897–1904.
Morgan BJ, Dempsey JA, Pegelow DF, et al: Blood pressure perturbations caused by subclinical sleep-disordered breathing. Sleep 1998; 21: 737–746.
Narkiewicz K, Somers VK : Sympathetic nerve activity in obstructive sleep apnoea. Acta Physiol Scand 2003; 177: 385–390.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Cui, R., Tanigawa, T., Sakurai, S. et al. Associations of Sleep-Disordered Breathing with Excessive Daytime Sleepiness and Blood Pressure in Japanese Women. Hypertens Res 31, 501–506 (2008). https://doi.org/10.1291/hypres.31.501
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1291/hypres.31.501
Keywords
This article is cited by
-
Associations of snoring frequency with blood pressure among the lean Japanese population: the Toon Health Study
Journal of Human Hypertension (2020)
-
Prevalence of sleep-disordered breathing among women working in the aged care services in Japan
International Archives of Occupational and Environmental Health (2019)
-
Risk factors for snoring among Japanese men and women: a community-based cross-sectional study
Sleep and Breathing (2011)
-
Obstructive sleep apnea: its prevention and screening may contribute to the prevention of hypertension, diabetes and cardiovascular diseases
EPMA Journal (2011)