Abstract
Natural populations of two semispecies of house mouse, Mus musculus domesticus and M.m. musculus, were found to be polymorphic for an aberrant chromosome 1 bearing a large inserted block of homogeneously staining heterochromatin. Strong meiotic drive for the aberrant chromosome from M.m. musculus was previously observed in heterozygous female mice. There are at least three meiotic drive levels determined by different allelic variants of distorter. Homozygotes had low viability and females showed low fertility. Both homo- and heterozygous males had normal fertility and their segregation patterns did not deviate from normal. Computer simulations were performed of the dynamics of aberrant chromosome 1 in demes and populations. The data demonstrate that a spontaneous mutation (inversion) of an aberrant chromosome 1, once arisen, has a high probability of spreading in a population at high coefficients of meiotic drive and migration. In the long-term, the population attains a stationary state which is determined by the drive level and migration intensity. The state of stable genotypic equilibrium is independent of deme and population size, as well as of the initial concentration of the aberrant chromosome. As populations initially polymorphic for the distorters approach the stationary state, the stronger distorter is eliminated. The frequencies of the aberrant chromosome determined by computer analysis agree well with those obtained for the studied Asian M.m. musculus populations. The evolutionary pathways for the origin and fixation of the aberrant chromosome in natural populations are considered.
Similar content being viewed by others
Article PDF
References
Agulnik, S, Agulnik, A, and Ruvinsky, A. 1990a. Meiotic drive in female mice heterozygous for the HSR inserts on chromosome 1. Genet Res, 55, 97–100.
Agulnik, S, Borodin, P, Gorlov, I, Ladygina, T, and Pak, S. 1990b. The origin of a double insertion of homogeneously staining regions in the house mouse (Mus musculus musculus). Heredity, 65, 265–267.
Agulnik, S, Gorlov, I, and Agulnik, A. 1988. New variant of chromosome 1 in the house mouse Mus musculus. Tsitologia, 30, 773–776.(In Russian.)
Agulnik, S I, Sabantsev, I D, Orlova, G V, and Ruvinsky, A O. 1993. Meiotic drive on aberrant chromosome 1 is determined by a linked distorter in the mouse. Genet Res. (in press a).
Agulnik, S I, Sabantsev, I D, and Ruvinsky, A O. 1993. Effect of sperm genotype on chromatid segregation in female mice heterozygous for aberrant chromosome 1. Genet Res. (in press b).
Boldyreff, B, Winking, H, Weith, A, and Traut, W. 1988. Evidence for in situ amplification of a germ line homogeneously staining region in the mouse. Cytogenet Cell Genet, 47, 84–85.
Brittnacher, J G, and Ganetzky, B. 1989. On the components of segregation distortion in Drosophila melanogaster. Genetics, 121, 739–750.
Crow, J F. 1988. Perspectives. Anecdotal, historical and critical commentaries on genetics. The ultraselfish genes. Genetics, 118, 389–391.
Dyakonov, V P. 1987. A Reference Book for Algorithms and Programmes on BASIC for Personal Computers, Nauka, Moscow. (In Russian.)
Dyban, A P, and Baranov, V S. 1978. Cytogenetics of Mammalian Development, Nauka, Moscow, pp. 216–218. (In Russian.)
Lewontin, R C. 1962. Interdeme selection controlling a polymorphism in the house mouse. Am Nat, 96, 65–78.
Lewontin, R C, and Dunn, L C. 1960. The evolutionary dynamics of a polymorphism in the house mouse. Genetics, 45, 705–722.
Petras, M L. 1967. Studies of natural populations of Mus. 1. Biochemical polymorphisms and their bearing on breeding structure. Evolution, 21, 259–274.
Silver, L M. 1985. Mouse t haplotypes. Ann Rev Genet, 19, 179–208.
Traut, W, Winking, H, and Adolph, S. 1984. An extra segment in chromosome 1 of wild Mus musculus: C-band positive homogeneously staining region. Cytogenet Cell Genet, 38, 290–297.
Weith, A, Winking, A, Brackmann, B, Boldyreff, B, and Traut, W. 1987. Microclones from a mouse germ line HSR detect amplification and complex rearrangements of DNA sequences. The EMBO Journal, 6, 1295–1300.
Winking, H, Bostelmann, H, and Fredga, K. 1991a. Incidence of double-band HSRs in chromosome 1 of the house mouse, Mus musculus musculus, from Oland (Sweden): a population study. Hereditas, 114, 111–116.
Winking, H, Weith, A, Boldyreff, B, Moriwaki, K, Fredga, K, and Traut, W. 1991b. Polymorphic HSRs in chromosome 1 of the two semispecies Mus musculus musculus and Mus musculus domesticus have a common origin in an ancestral population. Chromosoma, 100, 147–151.
Yakimenko, L, and Korobitsyna, K. 1988. A rare variant of chromosome 1 in house mouse: occurrence of two extra heterochromatin segments. Genetika, 24, 376–378. (In Russian.)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sabantsev, I., Spitsin, O., Agulnik, S. et al. Population dynamics of aberrant chromosome 1 in mice. Heredity 70, 481–489 (1993). https://doi.org/10.1038/hdy.1993.70
Received:
Issue Date:
DOI: https://doi.org/10.1038/hdy.1993.70
Keywords
This article is cited by
-
Meiotic drive in female mice: an essay
Mammalian Genome (1995)