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Selection in highly inbred populations of Drosophila melanogaster polymorphic at a single locus

Abstract

The polymorphic Esterase-6 system in Drosophila melanogaster has been studied in laboratory populations made up from highly inbred lines. The Est-6S and Est-6F homozygous lines were obtained after 100 generations of inbreeding, selecting heterozygotes at each generation. The level of homogeneity in the genetic background of the lines has been estimated by computer simulation of the inbreeding process and confirmed by electrophoresis. The experimental populations were cultured on a control medium and on media containing different concentrations of naturally occurring esters known to be rapidly utilised by Esterase-6. The results indicate significant genotype-environment interactions. The high level of genetic homogeneity of the lines and the specific pressure applied to the locus analysed suggest that the fitness effects observed could be reasonably attributed to Est-6 allozymes.

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This paper is dedicated to Professor Giuseppe Montalenti on the occasion of his 80th birthday.

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Costa, R., Nigro, L., Cambissa, V. et al. Selection in highly inbred populations of Drosophila melanogaster polymorphic at a single locus. Heredity 54, 195–202 (1985). https://doi.org/10.1038/hdy.1985.26

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