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TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians

Genes & Immunity volume 14, pages 268–270 (2013)Cite this article

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Abstract

Haplotypes spanning the tumor necrosis factor (TNF) gene block in the central major histocompatibility complex were defined in a Southern African population using 31 single-nucleotide polymorphisms. Twenty haplotypes accounted for 91.8% of the cohort. The haplotypes matched those described previously in Caucasian and Asian populations, supporting the hypothesis that TNF block haplotypes are ancient and highly conserved. They are presented here as a tool for disease-association studies.

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Acknowledgements

We thank Professor Ivo Gut, Steven McGinn and Jean-Guillaume Garnier of the Centre National de Génotypage (France) for the genotyping. We thank Campbell Witt for access to DNA samples from the Busselton Survey (Western Australia).

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Authors and Affiliations

  1. School of Pathology and Laboratory Medicine, University of Western Australia, Western Australia, Australia

    C S N Chew & P Price

  2. Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    A L Wadley, P R Kamerman & P Price

  3. Wits Bioinformatics, University of the Witwatersrand, Johannesburg, South Africa

    Z Lombard

  4. Division of Human Genetics, School of Pathology, Faculty of Health Sciences, National Health Laboratory Service and University of the Witwatersrand, Johannesburg, South Africa

    Z Lombard

Authors
  1. C S N Chew
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  2. A L Wadley
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  3. Z Lombard
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  4. P R Kamerman
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  5. P Price
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Correspondence to P Price.

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Chew, C., Wadley, A., Lombard, Z. et al. TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians. Genes Immun 14, 268–270 (2013). https://doi.org/10.1038/gene.2013.8

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