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  • Letter to the Editor
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Reply to ‘Comment on No association of primary Sjögren’s syndrome with Fcγ receptor gene variants’

Genes & Immunity volume 14, page 532 (2013)Cite this article

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We would like to thank Dr Lester et al.1 for their comments regarding our publication in Genes and Immunity, and we appreciate the opportunity to reply and clarify our findings.

Our results are therefore still in contrast to the studies by Nossent et al.,3 which found association with low copy number, and Mamtani et al.4 reporting association with both low and high copy number. Although all three papers2, 3, 4 followed the same criteria for classification of pSS,5 there were differences between the cohorts. While Mamtani et al.4 analyzed 61 patients with pSS, all of whom had a focus score >1, this was the case for only 74% of our patients. Moreover, all three studies2, 3, 4 included only a limited number of patients with pSS (n=61, n=174, and n=135, respectively) from different geographical areas.

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Figure 1

References

  1. Lester S, Nossent J, Rischmueller M . Comment on ‘No association of primary Sjögren’s syndrome with Fcγ receptor gene variants’. Genes Immun 2013; 14: 530–531.

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  2. Haldorsen K, Appel S, Le Hellard S, Bruland O, Brun JG, Omdal R et al. No association of primary Sjögren’s syndrome with Fcγ receptor gene variants. Genes Immun 2013; 14: 234–237.

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  3. Nossent JC, Rischmueller M, Lester S . Low copy number of the Fc-γ receptor 3B gene FCGR3B is a risk factor for primary Sjogren’s syndrome. J Rheumatol 2012; 39: 2142–2147.

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  4. Mamtani M, Anaya JM, He W, Ahuja SK . Association of copy number variation in the FCGR3B gene with risk of autoimmune diseases. Genes Immun 2010; 11: 155–160.

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  5. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE et al. Classification criteria for Sjogren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61: 554–558.

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Authors and Affiliations

  1. Department of Rheumatology, Haukeland University Hospital, Bergen, Norway

    K Haldorsen

  2. Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway

    O Bruland

  3. Department of Clinical Science, Broegelmann Research Laboratory, University of Bergen, Bergen, Norway

    S Appel

  4. Department of Clinical Dentistry, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway

    A I Bolstad

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  1. K Haldorsen
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  2. O Bruland
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  3. S Appel
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  4. A I Bolstad
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Correspondence to K Haldorsen.

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Haldorsen, K., Bruland, O., Appel, S. et al. Reply to ‘Comment on No association of primary Sjögren’s syndrome with Fcγ receptor gene variants’. Genes Immun 14, 532 (2013). https://doi.org/10.1038/gene.2013.51

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