Abstract
Purpose The safety and efficacy of prescribing a single maternal course of corticosteroid during pregnancy has been documented in human trials. However, the current trend is to prescribe repeated courses of corticosteroid. We investigated an aspect of the safety of this practice in an animal model.
Methods Date-mated ewes received saline, single or four corticosteroid injections between days 104 and 124 of gestation (term = 150). Lambs were delivered on day 125 or 145 by caesarian section after spinal anaesthesia. Eye diameters were measured and semi-thin toluidine-blue-stained transverse sections of retinae were analysed using an Optimus Image Analysis program.
Results At 125 days, retinal measures in the ventral periphery and area centralis were significantly thinner than control (p = 0.0001). At 145 days, total eye size was significantly reduced compared with control (p = 0.03), and retinal measures in the ventral periphery (p = 0.0001), but not the area centralis (p = 0.19), remained significantly different from control.
Conclusion Repeated maternal administration of corticosteroid may affect retinal maturation in the fetus.
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Grant support: Raine Medical Research Foundation, National Health and Medical Research Council (NH&MRC, Australia), Program grant 952304 and NH&MRC postgraduate scholarship for JAQ.
Part of this work was presented at the 1999 Australian Neuroscience Society and Perinatal Society of Australia and New Zealand annual scientific meetings
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Quinlivan, J., Beazley, L., Evans, S. et al. Retinal maturation is delayed by repeated, but not single, maternal injections of betamethasone in sheep. Eye 14, 93–98 (2000). https://doi.org/10.1038/eye.2000.20
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DOI: https://doi.org/10.1038/eye.2000.20
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