Abstract
Purpose To investigate the effect of indocyanine green in enhancing the effect of diode laser for treatment of circumscribed choroidal haemangioma.
Methods Intravenous indocyanine green was used to enhance uptake of heat energy during transpupillary diode thermotherapy of circumscribed choroidal haemangioma.
Results In a series of 6 patients treated in this manner, response to treatment was much improved compared with results without the use of indocyanine green. All patients retained the same or better visual acuity after treatment, and 67% of eyes improved visual acuity by more than 2 lines on Snellen testing. Ultrasonographic and angiographic evidence of improvement was seen in all patients. Treatment complications were minimal, comprising transient worsening of preexisting cystoid macular oedema in one case, and a small macular branch vein occlusion in the retina overlying the treated area.
Conclusions The use of indocyanine green as a contrast medium during transpupillary thermotherapy allows consistent uptake of diode laser energy, and shortens the duration of laser burn required. It is a cost-effective, easily performed outpatient procedure, with lower morbidity than other treatment modalities.
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Witschell H, Font LR . Haemangioma of choroid: a clinicopathologic study of 71 cases and review of literature. Surv Ophthalmol 1976;20:415–31.
Anand R, Augsburger JJ, Shields A . Circumscribed choroidal haemangiomas. Arch Ophthalmol 1989;107:1338–42.
Humphrey WT . Choroidal haemangioma response to cryotherapy. Ann Ophthalmol 1979;11:100–4.
Sanborn GE, Augsburger JJ, Shields JA . Treatment of circumscribed choroidal haemangiomas. Am J Ophthalmol 1982;89:1374–80.
Shields JA . The expanding role of laser photocoagulation for intraocular tumours: the 1993 Christian Zweng Memorial Lecture. Retina 1994;14:310–22.
Schilling H, Sauverin W, Lommatzsch A, et al. Long term results after low dose ocular irradiation for choroidal haemangiomas. Br J Ophthalmol 1997;81:267–73.
Zografos L, Bercher L, Chamot L, et al. Cobalt-60 treatment of choroidal haemangiomas. Am J Ophthalmol 1996;121:190–9.
Madreperla SA, Hungerford JL, Plowman PN, et al. Choroidal haemangioma: visual and anatomic results of treatment by photocoagulation or radiation therapy. Ophthalmology 1997;104:1773–9.
Lanzetta P, Virgili G, Ferrari E, Menchini U . Diode laser photocoagulation of choroidal haemangioma. Int Ophthalmol 1996;19:239–47.
Othmane IS, Shields CL, Shields JA, et al. Circumscribed choroidal haemangioma managed by transpupillary thermotherapy. Arch Ophthalmol 1999;117:136–7.
Garcia-Arumi J, Ramsay LS, Guraya BC . Transpupillary thermotherapy for circumscribed choroidal haemangiomas. Ophthalmology 2000;107:351–7.
Shields CL, Shields JA, Carter J et al. Transpupillary thermotherapy for choroidal melanoma: tumour control and visual results in 100 consecutive cases. Ophthalmology 1998;105:581–90.
Augsberger JJ, Shields JA, Moffat KP . Circumscribed choroidal haemangiomas: long term visual prognosis. Retina 1981;1:56–61.
Brancato R, Pratesi R, Leoni G, et al. Histopathology of diode and argon laser lesions in rabbit retina: a comparative study. Invest Ophthalmol Vis Sci 1989;30:1504–10.
McHugh JDA, Marshall J, Capon M, et af . Transpupillary retinal photocoagulation in the eyes of rabbit and human using a diode laser. Laser Light Ophthalmol 1998;2:125–43.
Gabel VP, Birngruber R, Hillenkamp F . Visible and near infrared light absorption in pigment epithelium and choroid. In: Shimuzu K, editor. International congress series no. 450. XXI-II Concilium Ophthalmol Kyoto. Amsterdam, Oxford: Excerpta Medica, Elsevier, 1978:658–62.
Clover GM . The effects of argon and krypton photocoagulation on the retina: implications for the inner and outer blood retinal barriers. In: Gitter KA, Shatz H, Yannuzzi LA, et al., editors. Laser photocoagulation of retinal disease. San Francisco: Pacific Medical Press, 1998:11–8.
Chong LP, Ozler SA, de Queiroz JM Jr, Ligget PE . Indocyanine green-enhanced diode laser treatment of melanoma in a rabbit model. Retina 1993;13:251–9.
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Kamal, A., Watts, A. & Rennie, I. Indocyanine green enhanced transpupillary thermotherapy of circumscribed choroidal haemangioma. Eye 14, 701–705 (2000). https://doi.org/10.1038/eye.2000.187
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DOI: https://doi.org/10.1038/eye.2000.187
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