Abstract
In a prospective and randomised study, we compared the course of pulsed dye laser ab interno sclerostomy with the course of posterior lip sclerectomy in 25 rabbits. One eye of each rabbit was randomly selected to be treated with laser; the fellow eye underwent posterior lip sclerectomy. Intraocular pressure (IOP) determinations and slit lamp examinations were recorded pre-operatively, then every other day for 3 weeks on 21 of the rabbits. Histological examination was performed on the eyes of 3 randomly selected rabbits that were killed 72 hours post-operatively. Laser sclerostomy resulted in an average maximal drop in IOP of 9.5 mmHg on post-operative day 1, and posterior lip sclerectomy resulted in a similar drop of 10.5 mmHg (p = 0.43, t-test). By life-table analysis, 88% of eyes returned to within 2 mmHg of pre-operative IOP values within 7 days following either laser internal sclerostomy or posterior lip sclerectomy. There was no significant difference between laser internal sclerostomy and posterior lip sclerectomy eyes with respect to the number of days needed to return to within 2 mmHg of preoperative IOP values (p = 0.26, sign test of the life-table analysis). Pulsed dye laser internal sclerostomy appears to be as effective as posterior lip sclerectomy in lowering IOP in the rabbit model.
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References
Shields MB . Anatomic principles of glaucoma surgery. In: Kist K, editor. Textbook of glaucoma. Baltimore: Williams and Wilkins, 1987:458–87.
Heuer DK, Gressel MG, Parrish RK, et al. Trabeculectomy in aphakic eyes. Ophthalmology 1984;91:1045–51.
Jampel HD, Jabs DA, Quigley HA . Trabeculectomy with 5-fluorouracil for adult inflammatory glaucoma. Am J Ophthalmol 1990;109:168–73.
Allen RC, Bellows AR, Hutchinson BT, Murphy SD . Filtration surgery in the treatment of neovascular glaucoma. Ophthalmology 1982;89:1181–6.
Krupin T, Waltman SR . Complications in ophthalmic surgery. Philadelphia: JB Lippincott, 1984:1–22.
Katz LJ, Cantor LB, Spaeth GL . Complications of surgery in glaucoma: early and late bacterial endophthalmitis following glaucoma filtering surgery. Ophthalmology 1985;92:959–63.
Maumenee AE . External filtering operations for glaucoma: the mechanism of function and failure. Trans Am Ophthalmol Soc 1960;58:319–28.
Addicks EA, Quigley HA, Green R, Robin AL . Histologic characteristics of filtering blebs in glaucomatous eyes. Arch Ophthalmol 1983;101:795–8.
Tahery M, Lee DA . Review: pharmacologic control of wound healing in glaucoma filtration surgery. J Ocular Pharmacol 1989;5:155–79.
Hoskins HD Jr, Iwach AG, Drake MV, Schuster BL, Vassiliadis A, Crawford JB, Hennings DR . Subcon-junctival THC:YAG laser limbal sclerostomy ab externo in the rabbit. Ophthalmic Surg 1990;21:589–92.
Hoskins HD Jr, Iwach AG, Vassiliadis A, Drake M, Hennings DR . Subconjunctival THC:YAG laser thermal sclerostomy. Ophthalmology 1991;98:1394–400.
Jaffe GJ, Williams GA, Mieler WF, Radius RL . Ab interno sclerostomy with a high-powered argon endo-laser. Am J Ophthalmol 1988;106:391–6.
Berlin MS, Rajacich G, Duffy M, et al. Excimer laser photoablation in glaucoma filtering surgery. Am J Ophthalmol 1987;103:713–4.
Gherezghiher T, March WF, Koss MC, Nordquist RE . Neodymium-YAG laser sclerostomy in primates. Arch Ophthalmol 1985;103:1543–5.
March WF, Gherezghiher T, Koss MC, Nordquist RE . Histologic study of a neodymium:YAG laser sclerostomy. Arch Ophthalmol 1985;103:860–3.
Javitt JC, O'Connor SS, Wilson RP, Federman JL . Laser sclerostomy ab interno using a continuous wave neodymium:YAG laser. Ophthalmic Surg 1989;20:552–6.
Higginbotham EJ, Kao G, Peyman GA . Internal sclerostomy with a Nd:YAG contact laser vs thermal sclerostomy in rabbits. Ophthalmology 1988;95:385–90.
Margolis TI, Farnath DA, Puliafito CA . Midinfrared laser sclerostomy. Invest Ophthalmol Vis Sci 1988;29(Suppl):366.
March WF, Gherezghiher T, Koss MC, Nordquist RE . Experimental YAG laser sclerostomy. Arch Ophthalmol 1984;102:1834–6.
March WF, La Fuente H, Rol P . Improved goniolens for YAG sclerostomy. Ophthalmic Surg 1987;18:513.
Latina MA, Dobrogowski M, March WF, Birngruber R . Laser sclerostomy by pulsed-dye laser and goniolens. Arch Ophthalmol 1990;108:1745–50.
Ruben S, Migdal C, DeVivero C . Ab interno pulsed dye laser sclerostomy for the treatment of glaucoma: preliminary results of a new technique. Eye 1993;7:436–9.
Melamed S, Solomon A, Neumann D, Hirsh A, Blumenthal M, Belkin M . Internal sclerostomy using laser ablation of dyed sclera in glaucoma patients: a pilot study. Br J Ophthalmol 1993;77:139–44.
Holt JD, Prentice RL . Survival analysis in twin studies and matched pair experiments. Biometrika 1974;61:17–30.
Seigel D, Podgor M . A sign test for significance of differences in survivorship curves from paired truncated data. Controlled Clin Trials 1982;3:69–71.
Troncoso MU, Castroviejo R . Microanatomy of the eye with the slit-lamp microscope. I. Comparative anatomy of the angle of the anterior chamber in living and sectioned eyes of Mammalia. Am J Ophthalmol 1942;19:371–84.
Miller MH, Joseph NH, Ennis KW, et al. An animal model of filtration surgery. Trans Ophthalmol Soc UK 1985;104:893–7.
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Rabowsky, J., Dukes, A. & Lee, D. Gonioscopic laser sclerostomy versus filtration surgery in a rabbit model. Eye 11, 830–837 (1997). https://doi.org/10.1038/eye.1997.214
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DOI: https://doi.org/10.1038/eye.1997.214