Abstract
Botulinum toxin type A (BTA) treatment is an alternative to strabismus surgery. In this retrospective study the data on 45 esotropic and 49 exotropic patients with concomitant strabismus who were treated with BTA were analysed for dose-effect relationship, the effect of repeat doses and amblyopia on success of botulinum treatment. The esotropic patients were treated with a total of 80 and exotropic patients with 91 injections. The deviations were corrected within 5 degrees of straight in 33% of esotropic and 18% of exotropic patients. In esotropic patients the effect was dose dependent. This relation was not shown in exotropic patients. The repeat doses of BTA corrected the deviation to the same extent as the primary ones for both esotropic and exotropic patients.
Similar content being viewed by others
Article PDF
References
Osako M, Keltner JL . Botulinum A toxin (Oculinum) in ophthalmology. Surv Ophthalmol 1991;36:28–46.
Lingua RW . Sequelae of botulinum toxin injection. Am J Ophthalmol 1985;100:305–7.
Scott AB, Magoon EH, McNeer KW, Stager DR . Botulinum treatment of childhood strabismus. Ophthalmology 1990;97:1434–8.
Scott AB . Botulinum toxin injection of eye muscles to correct strabismus. Trans Am Ophthalmol Soc 1981;79:734–70.
Scott AB . Antitoxin reduced botulinum side effects. Eye 1988;2:29–32.
Scott AB . Botulinum toxin treatment of strabismus. Focal points. Clinical modules for ophthalmologists. 7 (Mod 12), 1989:1–11.
Biglan AW, Burnstine RA, Rogers GL, Saunders RA . Management of strabismus with botulinum A toxin. Ophthalmology 1989;96:935–43.
Magoon EH . Botulinum toxin in the management of strabismus. In: Albert DM, Jacobiec FA, editors. Principles and practice of ophthalmology. Philadelphia: WB Saunders, 1994:2755–60.
Elston JS, Lee JP, Powell CM, Hogg, C, Clark P . Treatment of strabismus in adults with botulinum toxin A. Br J Ophthalmol 1985;69:718–24.
Gammon JA, Gemmill M, Tigges J, Lerman S . Botulinum chemodenervation treatment of strabismus. J Pediatr Ophthalmol Strabismus 1985;22:221–6.
Carruthers JDA . Ophthalmic use of botulinum A exotoxin. Can J Ophthalmol 1985;20:135–41.
Spencer FR, McNeer KW . Botulinum toxin paralysis of adult monkey extraocular muscle. Arch Ophthalmol 1987;105:1703–11.
Curruthers JDA, Kennedy RA, Bagaric D . Botulinum vs adjustable suture surgery in treatment of horizontal misalignment in adult patients lacking fusion. Arch Ophthalmol 1990;108:1432–5.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Abbasoglu, O., Sener, E. & Sanac, A. Factors influencing success and dose-effect relation of botulinum a treatment. Eye 10, 385–391 (1996). https://doi.org/10.1038/eye.1996.78
Issue Date:
DOI: https://doi.org/10.1038/eye.1996.78