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Orbital disease in herpes zoster ophthalmicus


Three cases of orbital inflammatory disease caused by herpes zoster are described. This extremely rare complication occurred between 5 days and 14 days following the skin eruption and slowly resolved with or without treatment. Biopsy of a chronic inflammatory lesion on the cheek of one patient demonstrated a sterile vasculitis and granulomatous Iiponecrosis, a process which may underlie the orbital disease in these patients.


  1. 1

    Burgoon CF, Burgoon JS, Baldridge GD . The natural history of herpes zoster ophthalmicus. JAMA 1957;75:193–6.

    Google Scholar 

  2. 2

    Edgerton AE . Herpes zoster ophthalmicus. Arch Ophthalmol 1945;93:40–114.

    Article  Google Scholar 

  3. 3

    de Moragas JM, Kierland RR . The outcome of patients with herpes zoster ophthalmicus. Arch Dermatol 1957;75:193–6.

    CAS  Article  Google Scholar 

  4. 4

    Worster-Drought C . Herpes zoster with localised muscular paralysis. BMJ 1923;1:970.

    CAS  Article  Google Scholar 

  5. 5

    Glyn C, Crockford, Gavaghan D . Epidemiology of shingles. J R Soc Med 1990;83:617–9.

    Article  Google Scholar 

  6. 6

    Marsh RJ, Cooper M . Ophthalmic herpes zoster. Eye 1993;7:350–70.

    Article  Google Scholar 

  7. 7

    Womack LW, Liesegang TJ . Complications of herpes zoster ophthalmicus. Arch Ophthalmol 1983;101:42–5.

    CAS  Article  Google Scholar 

  8. 8

    Harding SP, Lipton JR, Wells JCD . Natural history of herpes zoster ophthalmicus: predictors of post-herpetic neuralgia and ocular involvement. Br J Ophthalmol 1987;71:353–8.

    CAS  Article  Google Scholar 

  9. 9

    Scheie HG . Herpes zoster ophthalmicus. Trans Ophthalmol Soc UK 1970;90:899–937.

    CAS  Google Scholar 

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Correspondence to Geoffrey E Rose.

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Vardy, S., Rose, G. Orbital disease in herpes zoster ophthalmicus. Eye 8, 577–579 (1994).

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  • Herpes zoster ophthalmicus
  • Lipogranuloma
  • Orbital inflammation


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