Abstract
The extract from Smilax china root has been used as medicinal remedy and reported to retain antimicrobial and antimutagenic acitivities. In this study, a possible presence of antioxidant activity of Smilax china root extract was investigated. Methanol extract (Me) revealed the presence of high 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity (IC50 7.4 µg/ml) and protective property of cell's viability. Further fractionation with various solvent extraction and assay showed high levels of DPPH free radical scavenging activity in the ethyl acetate, butanol and water extracted fractions. In addition, V79-4 cells treated with Me of Smilax china root induced an increase of superoxide dismutase, catalase and glutathione peroxidase activities in a dose-dependent manner between 4-100 µg/ml. These results suggest that the medicinal component of the root of Smilax china extracts also contains antioxidant activity.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Lee, S., Ju, E. & Kim, J. Free radical scavenging and antioxidant enzyme fortifying activities of extracts from Smilax china root. Exp Mol Med 33, 263–268 (2001). https://doi.org/10.1038/emm.2001.43
Published:
Issue Date:
DOI: https://doi.org/10.1038/emm.2001.43
Keywords
This article is cited by
-
Therapeutic potential of Smilax fluminensis ethanolic extract: antitumoral activity in murine melanoma cells
Molecular and Cellular Biochemistry (2022)
-
Hypoglycaemic activity of Smilax canellifolia Mill. rhizomes: a bioassay-guided isolation and identification of synergistic compounds
Clinical Phytoscience (2021)
-
Antioxidant Activities of Hydroalcoholic Extract of Ocimum sanctum Against Cadmium Induced Toxicity in Rats
Indian Journal of Clinical Biochemistry (2010)
-
Investigation on Semecarpus Lehyam?a Siddha medicine for breast cancer
Planta (2005)
-
Rasagenthi lehyam (RL) a novel complementary and alternative medicine for prostate cancer
Cancer Chemotherapy and Pharmacology (2004)