Abstract
The objective of this study was to evaluate the effect of 8 weeks of no alcohol, low (1 drink or 15 g/day) and moderate (2 drinks or 30 g/day) alcohol consumption on markers of bone health: fasting serum 25-hydroxy vitamin D (25(OH)D), osteocalcin (OC), bone-specific alkaline phosphatase (BSAP), urine deoxypyridinoline (DPD) and helical peptide (HP) in postmenopausal women (n=51). Compared with no alcohol, 1 or 2 drinks/day for 8 weeks had no significant impact on any of the bone markers. Within each alcohol group, obese women had significantly lower serum 25(OH)D and higher DPD concentrations than normal weight women. Season significantly affected the concentrations of serum 25(OH)D, but there was no significant interaction between alcohol and season on serum 25(OH)D concentrations. Low or moderate alcohol consumption for 8 weeks had no significant impact on markers of bone health in postmenopausal women.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dorgan JF, Baer DJ, Albert PS, Judd JT, Brown ED, Corle DK et alSerum hormones and the alcohol-breast cancer association in postmenopausal women. J Natl Cancer Inst 2001; 93: 710–715.
Shiraz L, Almquist M, Malm J, Wirfalt E, Manjer J . Determinants of serum levels of vitamin D: a study of life-style, menopausal status, dietary intake, serum calcium, and PTH. BMC Women's Health 2013; 13: 33.
Marrone J, Maddalozzo G, Branscum A, Hardin K, Cialdella-Kam L, Philbrick K et alModerate alcohol intake lowers biochemical markers of bone turnover in postmenopausal women. Menopause 2012; 19: 974–979.
Parikh S, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J, Yanovski JA . The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 2004; 89: 1196–1199.
Giovannucci E, Rimm EB, Hollis BW, Fuchs CS, Stampfer MJ, Willett WC . Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 2006; 98: 451–459.
Wortsman J ML, Chen TC, Lu Z, Holick MF . Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72: 690–693.
Acknowledgements
This study was supported by NIH and the National Cancer Institute Interagency agreement Y1-SC-8012 and the Intramural Research Program.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Mahabir, S., Baer, D., Pfeiffer, R. et al. Low to moderate alcohol consumption on serum vitamin D and other indicators of bone health in postmenopausal women in a controlled feeding study. Eur J Clin Nutr 68, 1267–1270 (2014). https://doi.org/10.1038/ejcn.2014.191
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/ejcn.2014.191
This article is cited by
-
Lifestyle is associated with atrial fibrillation development in patients with type 2 diabetes mellitus
Scientific Reports (2021)
-
Lifestyle and 25-hydroxy-vitamin D among community-dwelling old adults with dementia, mild cognitive impairment, or normal cognitive function
Aging Clinical and Experimental Research (2020)