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SNP276G>T polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with Type II diabetes mellitus in Korea

European Journal of Clinical Nutrition volume 64, pages 105–107 (2010)Cite this article

Abstract

Few studies have examined an association between SNP276 and the risk of metabolic syndrome (MetS), which accelerates the development of diabetic complications, in patients with type II diabetes mellitus (T2DM). This study examined whether the SNP276G>T polymorphism is associated with risk of MetS in 673 Korean patients with T2DM from an ongoing prospective study. Multiple logistic regression analysis revealed that the OR for MetS was greater in patients with the TT genotype than in those with the GG genotype (OR=2.071; 95% CI=1.088–3.943) after adjustment of the putative risk factors for MetS. After examining the relationship between serum adiponectin and MetS risk for each genotype, only in patients with the GT genotype, serum adiponectin was negatively associated with the risk of MetS (OR=0.287; 95% CI=0.193–0.427). The SNP276G>T polymorphism may have an independent role in the determination of MetS in Korean patients with T2DM.

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References

  • Filippi E, Sentinelli F, Romeo S, Arca M, Berni A, Tiberti C et al. (2005). The adiponectin gene SNP+276G>T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients (age⩽50 years). J Mol Med 83, 711–719.

    Article  CAS  Google Scholar 

  • Haluzík M, Parízková J, Haluzík MM (2004). Adiponectin and its role in the obesity-induced insulin resistance and related complications. Physiol Res 53, 123–129.

    Google Scholar 

  • Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y et al. (2000). Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20, 1595–1599.

    Article  CAS  Google Scholar 

  • Jang Y, Chae JS, Koh SJ, Hyun YJ, Kim JY, Jeong YJ et al. (2008). The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women. Clin Chim Acta 391, 85–90.

    Article  CAS  Google Scholar 

  • Kim SM, Cho KH, Park HS (2006). Relationship between plasma adiponectin levels and the metabolic syndrome among Korean people. Endocr J 53, 247–254.

    Article  CAS  Google Scholar 

  • Lee YY, Lee NS, Cho YM, Moon MK, Jung HS, Park YJ et al. (2005). Genetic association study of adiponectin polymorphisms with risk of type 2 diabetes mellitus in Korean population. Diabet Med 22, 569–575.

    Article  CAS  Google Scholar 

  • Shin MJ, Jang Y, Koh SJ, Chae JS, Kim OY, Lee JE et al. (2006). The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss. Int J Obesity 30, 1702–1708.

    Article  CAS  Google Scholar 

  • Yang WS, Chuang LM (2006). Human genetics of adiponectin in the metabolic syndrome. J Mol Med 84, 112–121.

    Article  CAS  Google Scholar 

  • Yang WS, Yang YC, Chen CL, Wu IL, Lu JY, Lu FH et al. (2007). Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly. Am J Clin Nutr 86, 509–513.

    Article  CAS  Google Scholar 

  • Yu SY, Ryu HK, Park HJ, Choi YJ, Huh KB, Kim WY (2007). Adiponectin gene SNP 276G → T, nutrient intakes, and cardiovascular disease risk in Korean type 2 DM patients. Nutr Res Pract 1, 363–370.

    Article  CAS  Google Scholar 

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Acknowledgements

Supported by Seoul R&BD Program, no.10526, and by the second stage of the BK Project in 2008.

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Authors and Affiliations

  1. Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea

    J-Y Hwang, J E Park & W Y Kim

  2. 21C Diabetics and Vascular Research Center, Seoul, Korea

    Y J Choi & K B Huh

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  1. J-Y Hwang
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  2. J E Park
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  3. Y J Choi
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  4. K B Huh
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  5. W Y Kim
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Correspondence to W Y Kim.

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Hwang, JY., Park, J., Choi, Y. et al. SNP276G>T polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with Type II diabetes mellitus in Korea. Eur J Clin Nutr 64, 105–107 (2010). https://doi.org/10.1038/ejcn.2009.94

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  • DOI: https://doi.org/10.1038/ejcn.2009.94

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