The spectrum of secondary immunodeficiency (SID) associated with B-cell lymphoproliferative diseases (B-CLPD) primarily encompasses defects in antibody production and hypogammaglobulinemia, alongside varying T cell and innate immunity defects.
As with primary immunodeficiency disorders (PID), a classification system is warranted to categorize SID defects and assess infection risk. Despite similarities in infection profiles between PID and SID to B-CLPD, it is of utmost importance to rule out PID at B-CLPD diagnosis, which has clinical and prognostic implications for the patients and their families.
This webcast will explore the genomic landscape of B-CLPD and its intersection with PID, underscoring potential shared pathways and therapeutic targets. A highlight will be an integrated approach incorporating immunological biomarkers alongside traditional prognostic indicators as essential for enhancing diagnostic accuracy and tailoring risk-adapted therapies in patients with B-CLPD and concurrent immune dysfunction.
You will learn:
• The clinical relevance of an adequate assessment and classification of B-CLPD immunodeficiency in predicting disease progression and informing treatment decisions
• Challenges in diagnosing primary versus secondary immunodeficiency and the importance of early recognition
• The relevance of interdisciplinary collaboration and integrated approaches to patient care
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This webcast has been produced by BD Biosciences, who retails sole responsibility for content. About this content.
Speaker
Silvia Sánchez-Ramón, Head, Immunology Department, Hospital Clínico San Carlos, Madrid
Silvia Sánchez Ramón MD, PhD, is the Head of the Immunology Department at the Hospital Clínico San Carlos, and an associate professor at the Faculty of Medicine of the Universidad Complutense de Madrid. She trained at the Hospital Gregorio Marañón, with internships at the Institut Curie in Paris, the Mount Sinai Medical Center in New York, and the Hôpital Necker Enfants Malades in Paris. She is a member of the Medical Advisory Committee of the International Patient Organization for Primary Immunodeficiencies (IPOPI), and the president-elect of the Spanish Society of Immunology. She works as a clinical immunologist and researcher in the field of primary and secondary immunodeficiencies and immunoregulation. She is the author of over 200 international publications and serves as an associate editor of Frontiers in Cellular Neuroscience.
Moderator
Sarah Hiddleston, Nature Research Custom Media
Sarah Hiddleston is a freelance journalist who has worked with Nature Research Custom Media since 2015. Previously, Sarah worked for a decade in Madras (Chennai), India, specialising in health, pharmaceutical and environmental stories. Sarah holds an MA in Investigative Journalism from City University London, an MSc in Political Theory from the London School of Economics, and an undergraduate degree in History from the University of Cambridge, UK.
