Cancer treatment based on immunotherapy through immune checkpoint inhibitors (ICIs) has been demonstrated to be an effective way to activate the immune system against tumor cells. ICIs are monoclonal antibodies that enhance existing immune responses by blocking the inhibitory molecules on T cells (CTLA-4 and PD-1) and antigen-presenting cells (PD-L1). Although ICIs induce a strong anti-tumor response, they have also been shown to induce immune-related adverse events (irAEs) in a wide variety of tissues, of which cardiac irAEs are among the deadliest.
This webcast will present a recent meta-analysis of clinical trials and pharmacovigilance analysis to determine the incidence of cardiac irAEs in patients treated with ICIs, as well as efforts to determine the mechanisms behind them.
Learning objectives:
• Gain an understanding of cardiac adverse events associated with immune checkpoint inhibitors
• Find out about the underlying mechanisms that lead to such cardiac adverse events
• Discuss possible alternative treatments
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This webcast has been produced by Tecnológico de Monterrey, who retails sole responsibility for content. About this content.
Speakers
Guillermo Torre Amione, Vice President of Research, Tecnológico de Monterrey
Guillermo Torre Amione, MD, PhD, is Rector of TecSalud and Vice President of Research at Tecnológico de Monterrey, and is one of the founders of the Transplant Laboratory at Houston Methodist Hospital. Dr. Torre Amione is a member of the National Academy of Medicine, the American College of Cardiology, and the American Heart Association; he is certified as a specialist in Clinical Cardiology by the Mexican Council of Cardiology and certified in Internal Medicine, Cardiology, Heart Failure, and Transplantation by the American Board of Internal Medicine.
Elena Cristina Castillo, Research Professor, Tecnológico de Monterrey
Elena Cristina Castillo is a Research Professor at Tecnológico de Monterrey in the group of Experimental Medicine Advanced Therapies from the Institute of Obesity Research. She is an immunologist with a bachelor's degree in biology. She has been working on the immune system related to heart failure and obesity as an associated risk factor. She is a member of the American Association of Immunologists and The International Society for Heart Research.
Moderator
Nikki Forrester, Freelance Science Writer and Editor
Nikki Forrester is a science journalist who covers biology, natural history, climate, and the culture of academic research. She earned a Ph.D. in ecology and evolutionary biology in 2019.
