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  • RESEARCH BRIEFINGS

Tracing the brain circuitry underlying movement and mood symptoms in Parkinson’s disease

Parkinson’s disease causes slowness of movement, tremor and stiffness, along with mood symptoms such as depression. The brain’s parafascicular thalamus is shown to contain distinct neural circuits for locomotion, motor learning and depression-like states, and targeting these circuits alleviates some deficits in a mouse model of the disease.

This is a summary of: Zhang, Y. et al. Targeting thalamic circuits rescues motor and mood deficits in PD mice. Nature https://doi.org/10.1038/s41586-022-04806-x (2022).

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doi: https://doi.org/10.1038/d41586-022-01465-w

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