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CRISPR-based gene therapy dampens pain in mice

Targeted approach could lead to an opioid-free way of treating chronic pain.
  1. Ariana Remmel
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A gene-silencing technique based on CRISPR can relieve pain in mice, according to a study1. Although the therapy is still a long way from being used in humans, scientists say it is a promising approach for squelching chronic pain that lasts for months or years. Chronic pain is typically treated with opioids such as morphine, which can lead to addiction.

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Nature 591, 359 (2021)

doi: https://doi.org/10.1038/d41586-021-00644-5

References

  1. Moreno, A. M. et al. Sci. Transl. Med. 13, eaay9056 (2021).

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  2. Breivik, H., Collett, B., Ventafridda, V., Cohen, R. & Gallacher, D. et al. Eur. J. Pain 10, 287 (2006).

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  3. Johannes, C. B., Le, T. K., Zhou, X., Johnston, J. A. & Dworkin, R. H. J. Pain 11, 1230–1239 (2010).

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