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  • RESEARCH HIGHLIGHT

Compound stops CRISPR enzyme running amok

A small molecule is identified that puts the brakes on the Cas9 enzyme.
Molecular model of the CRISPR-associated protein Cas9 in complex with RNA and DNA

Activity of the CRISPR–Cas9 complex (blue and pale green), a widely used tool for editing DNA (purple), can be tightly controlled thanks to the discovery of an inhibitor. Credit: Ella Maru Studio/SPL

A chemical inhibitor of the CRISPR–Cas9 gene-editing tool could allow researchers to switch editing on and off in living cells.

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Nature 569, 163 (2019)

doi: https://doi.org/10.1038/d41586-019-01412-2

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