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More than four decades into my scientific career, I find myself an outlier among academics of similar age and seniority: I strongly identify with the movement to make the practice of science more robust. It’s not that my contemporaries are unconcerned about doing science well; it’s just that many of them don’t seem to recognize that there are serious problems with current practices. By contrast, I think that, in two decades, we will look back on the past 60 years — particularly in biomedical science — and marvel at how much time and money has been wasted on flawed research.