While self-renewable, pluripotent human (h) embryonic stem cells (ESCs) can provide an unlimited source of donor cardiomyocytes (CMs) for myocardial repair, we showed in a preclinical large (porcine) animal transplantation model that their cardiac derivatives with immature properties are prime substrates for lethal cardiac arrhythmias. To address this, we developed an approach for driven maturation of hESC-derived CMs (hESCCMs) that renders the cellular electrophysiological phenotype adult-like and thus completely ablates post-transplantation ventricular tachycardias (VT)/fibrillation (VF).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Fu, JD., Tse, Hf., Siu, CW. et al. Driven maturation of embryonic stem cell-derived cardiomyocytes confers post-transplantation safety. Cell Res 18 (Suppl 1), S132 (2008). https://doi.org/10.1038/cr.2008.222
Published:
Issue Date:
DOI: https://doi.org/10.1038/cr.2008.222
Keywords
This article is cited by
-
In Vitro Uses of Human Pluripotent Stem Cell-Derived Cardiomyocytes
Journal of Cardiovascular Translational Research (2012)