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Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome
Cell Death & Disease Open Access 11 January 2021
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References
Kaplan GG . The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol 2015; 12: 720–727.
Chen L, Wilson JE, Koenigsknecht MJ, Chou WC, Montgomery SA, Truax AD et al. NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth. Nat Immunol 2017; 18: 541–551.
Ananthakrishnan AN . Epidemiology and risk factors for IBD. Nat Rev Gastroenterol Hepatol 2015; 12: 205–217.
Waldner MJ, Neurath MF . Mechanisms of immune signaling in colitis-associated cancer. Cell Mol Gastroenterol Hepatol 2015; 1: 6–16.
Shi Y, Mu L . An expanding stage for commensal microbes in host immune regulation. Cell Mol Immunol 2017; 14: 339–348.
Zambetti LP, Mortellaro A . NLRPs, microbiota, and gut homeostasis: unravelling the connection. J Pathol 2014; 233: 321–330.
Williams TM, Leeth RA, Rothschild DE, Coutermarsh-Ott SL, McDaniel DK, Simmons AE et al. The NLRP1 inflammasome attenuates colitis and colitis-associated tumorigenesis. J Immunol 2015; 194: 3369–3380.
Corridoni D, Arseneau KO, Cifone MG, Cominelli F . The dual role of nod-like receptors in mucosal innate immunity and chronic intestinal inflammation. Front Immunol 2014; 5: 317.
Tuncer S, Fiorillo MT, Sorrentino R . The multifaceted nature of NLRP12. J Leukoc Biol 2014; 96: 991–1000.
Zaki MH, Man SM, Vogel P, Lamkanfi M, Kanneganti TD . Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection. Proc Natl Acad Sci USA 2014; 111: 385–390.
Allen IC, Wilson JE, Schneider M, Lich JD, Roberts RA, Arthur JC et al. NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-kappaB signaling. Immunity 2012; 36: 742–754.
Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 2011; 145: 745–757.
Chassaing B, Aitken JD, Malleshappa M, Vijay-Kumar M . Dextran sulfate sodium (DSS)-induced colitis in mice. Curr Protoc Immunol 2014; 104: Unit 15.25.
Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR . Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci USA 2007; 104: 13780–13785.
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Lau, JF., Dombrowski, Y. The innate immune receptor NLRP12 maintains intestinal homeostasis by regulating microbiome diversity. Cell Mol Immunol 15, 193–195 (2018). https://doi.org/10.1038/cmi.2017.61
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DOI: https://doi.org/10.1038/cmi.2017.61
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Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome
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