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Inhibition of neddylation ameliorates DSS-induced colitis

Cellular & Molecular Immunology volume 15, pages 649–650 (2018)Cite this article

Immune disorders are characterized by excessive immune cell activation and aberrant inflammatory responses. Cell signals have been noted to regulate immune cell functions and to contribute to immune diseases, for example, upon extracellular stimulation, cell receptor-mediated signals, including mammalian target of rapamycin/signal transducer and activator of transcription factor 31,2 and mitogen-activated protein kinase/nuclear factor-κB,3,4 induce the expression of proinflammatory cytokines and molecules, thereby resulting in immune cell activation and sustained inflammation, as seen in inflammatory bowel diseases and other immune disorders.

Beyond the active transcription of proinflammatory cytokines, posttranslational modifications have also been associated with inflammatory disorders.5 Posttranslational modification by the inflammasome promotes the maturation and activation of proinflammatory cytokines, interleukin (IL)-1β and IL-18 in particular, leading to the exacerbation of immune diseases.5 Recently, we noted that the inflammasome potentially mediates extracellular ATP/P2X7 receptor-driven dextran sulfate sodium (DSS) colitis,6 indicating the pivotal roles of the inflammasome in the regulation of immune responses in colitis.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China, Nos. 81770555, 81470828 and 81270472; the Principle Investigator Program of Jiangxi Province and the Natural Science Foundation of Jiangxi Province, No. 20142BAB205048 (all to A-PB).

Author contributions

A-PB designed the study; all authors conducted the experiments and collected the data; A-PB, X-DZ and YG performed data analysis and wrote and finalized the manuscript. All authors approved the final version for publication.

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Authors and Affiliations

  1. Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, China

    Ping Wan, Tao Yu, Run-Wei Yan & Ai-Ping Bai

  2. Transplant Center, Department of Surgery, the Affiliated Hospital of Qingdao University, Qingdao, 266555, China

    Xiao-Dan Zhu

  3. Department of Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510640, China

    Xiao-Peng Liu

  4. Department of Pharmacy, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, China

    Yuan Guo

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  1. Ping Wan
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Correspondence to Ai-Ping Bai.

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Wan, P., Zhu, XD., Liu, XP. et al. Inhibition of neddylation ameliorates DSS-induced colitis. Cell Mol Immunol 15, 649–650 (2018). https://doi.org/10.1038/cmi.2017.144

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