This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Thome R, Issayama LK, Digangi R, Bombeiro AL, da Costa TA, Ferreira IT et al. Dendritic cells treated with chloroquine modulate experimental autoimmune encephalomyelitis. Immunol Cell Biol 2014; 92: 124–132.
Niedbala W, Alves-Filho JC, Fukada SY, Vieira SM, Mitani A, Sonego F et al. Regulation of type 17 helper T-cell function by nitric oxide during inflammation. Proc Natl Acad Sci USA 2011; 108: 9220–9225.
Niedbala W, Besnard AG, Jiang HR, Alves-Filho JC, Fukada SY, Nascimento D et al. Nitric oxide-induced regulatory T cells inhibit Th17 but not Th1 cell differentiation and function. J Immunol 2013; 191: 164–170.
Kaneno R, Shurin GV, Kaneno FM, Naiditch H, Luo J, Shurin MR . Chemotherapeutic agents in low noncytotoxic concentrations increase immunogenicity of human colon cancer cells. Cell Oncol (Dordr) 2011; 34: 97–106.
Thome R, Issayama LK, Costa TA, Gangi RD, Ferreira IT, Raposo C et al. Dendritic cells treated with crude Plasmodium berghei extracts acquire immune-modulatory properties and suppress the development of autoimmune neuroinflammation. Immunology 2014; 143: 164–173.
Ghigo D, Aldieri E, Todde R, Costamagna C, Garbarino G, Pescarmona G et al. Chloroquine stimulates nitric oxide synthesis in murine, porcine, and human endothelial cells. J Clin Invest 1998; 102: 595–605.
Ahmed MH, Ashton N, Balment RJ . The effect of chloroquine on renal function and vasopressin secretion: a nitric oxide-dependent effect. J Pharmacol Exp Ther 2003; 304: 156–161.
Ahmed MH, Osman MM . Why does chloroquine impair renal function?: chloroquine may modulate the renal tubular response to vasopressin either directly by inhibiting cyclic AMP generation, or indirectly via nitric oxide. Med Hypotheses 2007; 68: 140–143.
Thome R, Moraes AS, Bombeiro AL, Farias AD, Francelin C, da Costa TA et al. Chloroquine treatment enhances regulatory T cells and reduces the severity of experimental autoimmune encephalomyelitis. PLoS One 2013; 8: e65913.
Niedbala W, Cai B, Liu H, Pitman N, Chang L, Liew FY . Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc Natl Acad Sci USA 2007; 104: 15478–15483.
Rossner S, Voigtlander C, Wiethe C, Hanig J, Seifarth C, Lutz MB . Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro. Eur J Immunol 2005; 35: 3533–3544.
Acknowledgements
This work was supported by the São Paulo Research Foundation (FAPESP, grant nos. 2011/17965-3 and #2013/08194-9). RT received a FAPESP scholarship (grant no. 2014/02631-0).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Verinaud, L., Issayama, L., Zanucoli, F. et al. Nitric oxide plays a key role in the suppressive activity of tolerogenic dendritic cells. Cell Mol Immunol 12, 384–386 (2015). https://doi.org/10.1038/cmi.2014.94
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/cmi.2014.94
This article is cited by
-
Chloroquine inhibits human CD4+ T-cell activation by AP-1 signaling modulation
Scientific Reports (2017)
-
Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer
Journal of Cancer Research and Clinical Oncology (2017)