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Butyrophilin 3A1 presents phosphoantigens to human γδ T cells: the fourth model of antigen presentation in the immune system

Cellular & Molecular Immunology volume 11, pages 123–125 (2014)Cite this article

T lymphocytes are major players in immunity, providing protection against pathogenic microorganisms and tumors. They achieve this goal because they express clonally distributed receptors (T-cell receptor, TCR) on their surface capable of recognizing antigens displayed on the surface of specialized antigen-presenting cells, in association with antigen presenting molecules.1

The situation for γδ T cells, an unconventional subset of so called innate memory T cells, has long remained obscure.2 In the blood of most healthy individuals, the predominant γδ T cell population consists of T cells expressing the Vδ2 gene paired with the Vγ9 chain.

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References

  1. Eckle SB, Turner SJ, Rossjohn J, McCluskey J . Predisposed αβ T cell antigen receptor recognition of MHC and MHC-I like molecules? Curr Opin Immunol 2013; 25: 1–7.

    Article  Google Scholar 

  2. Bonneville M, O'Brien RL, Born WK . γδ T cell effector functions: a blend of innate programming and acquired plasticity. Nat Rev Immunol 2010; 10: 467–478.

    Article  CAS  Google Scholar 

  3. Vantourout P, Hayday A . Six-of-the-best: unique contributions of γδ T cells to immunology. Nat Rev Immunol 2013; 13: 88–100.

    Article  CAS  Google Scholar 

  4. Vavassori S, Kumar A, Wan GS, Ramanjaneyulu GS, Cavallari M, El Daker S et al. Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells. Nat Immunol 2013; 14: 908–916.

    Article  CAS  Google Scholar 

  5. Sireci G, Champagne E, Fournié JJ, Dieli F, Salerno A . Patterns of phosphoantigen stimulation of human Vγ9Vδ2 T cell clones include Th0 cytokines. Hum Immunol 1997; 58: 70–82.

    Article  CAS  Google Scholar 

  6. Sireci G, Espinosa E, Di Sano C, Dieli F, Fournié JJ, Salerno A . Differential activation of human γδ cells by nonpeptide phosphoantigens. Eur J Immunol 2001; 31: 1628–1635.

    Article  CAS  Google Scholar 

  7. Allison TJ, Winter CC, Fournie JJ, Bonneville M, Garboczi DN . Structure of a human γδ T-cell antigen receptor. Nature 2001; 411: 820–824.

    Article  CAS  Google Scholar 

  8. Wang H, Fang Z, Morita CT . Vγ2Vδ2 T cell receptor recognition of prenyl pyrophosphates is dependent on all CDRs. J Immunol 2010; 184: 6209–6222.

    Article  CAS  Google Scholar 

  9. Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H, Bloom BR et al. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity 1995; 3: 495–507.

    Article  CAS  Google Scholar 

  10. Harly C, Guillaume Y, Nedellec S, Peigné CM, Mönkkönen H, Mönkkönen J et al. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset. Blood 2012; 120: 2269–2279.

    Article  CAS  Google Scholar 

  11. Palakodeti A, Sandstrom A, Sundaresan L, Harly C, Nedellec S, Olive D et al. The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. J Biol Chem 2012; 287: 32780–32790.

    Article  CAS  Google Scholar 

  12. Wang H, Henry O, Distefano MD, Wang YC, Räikkönen J, Mönkkönen J et al. Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 T cells. J Immunol 2013; 191: 1029–1042.

    Article  CAS  Google Scholar 

  13. Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L et al. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 2012; 491: 717–723.

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by grants from the Ministry of University and Research (MIUR-PRIN 2008) and the Ministry of Health ‘Ricerca Finalizzata 2007’ to FD.

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  1. Biomedical Research Centre and Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università di Palermo, Palermo, Italy

    Francesco Dieli, Raffaela Fadda & Nadia Caccamo

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  1. Francesco Dieli
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  2. Raffaela Fadda
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  3. Nadia Caccamo
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Correspondence to Francesco Dieli.

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Dieli, F., Fadda, R. & Caccamo, N. Butyrophilin 3A1 presents phosphoantigens to human γδ T cells: the fourth model of antigen presentation in the immune system. Cell Mol Immunol 11, 123–125 (2014). https://doi.org/10.1038/cmi.2013.54

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