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Nck, a missing adaptor between the B-cell receptor complex and the BCAP/PI3K/Akt pathway

Cellular & Molecular Immunology volume 11, pages 120–122 (2014)Cite this article

Antigen-triggered BCR crosslinking induces the tyrosine phosphorylation of immunoglobulin-α (Igα, CD79A) and immunoglobulin-β (Igβ, CD79B) by Src family kinases such as Lyn. BCR engagement also stimulates the tyrosine phosphorylation of CD19. The phosphorylation of Igα and Igβ stimulates the recruitment of the Syk tyrosine kinase (Figure 1) to the BCR complex and induces Syk phosphorylation and activation, which subsequently induces the phosphorylation of an adaptor protein, SLP-65 (also known as BLNK).10,11 Phosphorylated SLP-65 provides docking sites for phospholipase C-γ2, Bruton's tyrosine kinase,12,13 and another adaptor protein, Grb2,10 which initiates the activation of the Ras/Raf/MEK/ERK kinase cascade (Figure 1).

The Nck family is another group of adaptors that contains three Src-homology 3 (SH3) domains at its N-terminus and 1 SH2 domain at its C-terminus. Two members in the Nck family exist in mice and humans (Nck1 and Nck2). Nck proteins control the cytoskeletal rearrangement and mobility of kidney podocytes and neurons.14,15 In the immune system, Nck is known to associate with the T-cell receptor and regulate T-cell receptor signaling and T-cell development.16 However, the role of Nck in B cells is largely unknown, although SLP-65 is known to bind Nck.10

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  1. Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan

    Chuen-Miin Leu

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Leu, CM. Nck, a missing adaptor between the B-cell receptor complex and the BCAP/PI3K/Akt pathway. Cell Mol Immunol 11, 120–122 (2014). https://doi.org/10.1038/cmi.2013.53

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