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The Classical and Regulatory Functions of C1q in Immunity and Autoimmunity

Cellular & Molecular Immunology volume 5, pages 9–21 (2008)Cite this article

Abstract

A classical function of C1q is to bind immune complexes and initiate complement activation producing membrane lytic complexes, opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when C1q binds some other ligands. Besides complement activation, C1q also regulates cell differentiation, adhesion, migration, activation and survival. C1q deficiency is associated with autoimmunity as well as increased susceptibility to infections. In this article, we discuss the basic properties of C1q, its expression, and classical and regulatory functions.

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Authors and Affiliations

  1. Department of Microbiology, Yong Loo Lin School of Medicine and 2NUS Immunology Program, National University of Singapore, Blk MD4, 5 Science Drive 2, Singapore, 117597

    Jinhua Lu, Boon King Teh, Linda Wang, Yinan Wang, Yen Seah Tan & Min Chern Lai

  2. Department of Biochemistry, MRC Immunochemistry Unit, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK

    Kenneth B M Reid

Authors
  1. Jinhua Lu
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  2. Boon King Teh
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  3. Linda Wang
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  4. Yinan Wang
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  5. Yen Seah Tan
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  6. Min Chern Lai
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  7. Kenneth B M Reid
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Correspondence to Jinhua Lu.

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Lu, J., Teh, B., Wang, L. et al. The Classical and Regulatory Functions of C1q in Immunity and Autoimmunity. Cell Mol Immunol 5, 9–21 (2008). https://doi.org/10.1038/cmi.2008.2

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  • DOI: https://doi.org/10.1038/cmi.2008.2

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