Abstract
EBV infection is one of the life-threatening clinical complications in patients who underwent haploidentical hematopoietic stem cell transplantation (haploHSCT). Although immune recovery is recognized to be crucial for decreasing subsequent morbidity of infections, the link between T-cell recovery and EBV infection after haploHSCT remains elusive. We recently compared the influences of different doses of antithymocyte globulin conditioning on the T-cell reconstitution post haploHSCT and suggested that CD4−CD8−T cells might interact with the occurrence of EBV reactivation. In the current study, haploHSCT recipients with EBV-DNAemia (n=64) were compared with a control group without EBV reactivation (n=192), with regard to the recoveries of T-cell subpopulations. In contrast to other T-cell subpopulations, the median counts ofCD4−CD8−T cells in recipients with EBV-DNAemia were significantly lower than the control group at a serial time course (30, 90 and 180 days) after transplantation. Landmark studies further confirmed the correlation of CD4−CD8−T cells with the EBV infection. Multivariate analysis showed that hampered recovery of CD4−CD8−T cells and EBV reactivation were the independent risk factors to predict transplant-related mortality. Our findings may facilitate the intervention strategies to improve the overall survival of haploHSCT recipients.
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Acknowledgements
This study is supported by Key Program of the National Natural Science Foundation of China (Grant No 81230013) and National Natural Science Foundation of China (Grant No. 81370666).
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Bian, Z., Liu, J., Xu, LP. et al. Association of Epstein–Barr virus reactivation with the recovery of CD4/CD8 double-negative T lymphocytes after haploidentical hematopoietic stem cell transplantation. Bone Marrow Transplant 52, 264–269 (2017). https://doi.org/10.1038/bmt.2016.238
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DOI: https://doi.org/10.1038/bmt.2016.238
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