EBV infection is one of the life-threatening clinical complications in patients who underwent haploidentical hematopoietic stem cell transplantation (haploHSCT). Although immune recovery is recognized to be crucial for decreasing subsequent morbidity of infections, the link between T-cell recovery and EBV infection after haploHSCT remains elusive. We recently compared the influences of different doses of antithymocyte globulin conditioning on the T-cell reconstitution post haploHSCT and suggested that CD4−CD8−T cells might interact with the occurrence of EBV reactivation. In the current study, haploHSCT recipients with EBV-DNAemia (n=64) were compared with a control group without EBV reactivation (n=192), with regard to the recoveries of T-cell subpopulations. In contrast to other T-cell subpopulations, the median counts ofCD4−CD8−T cells in recipients with EBV-DNAemia were significantly lower than the control group at a serial time course (30, 90 and 180 days) after transplantation. Landmark studies further confirmed the correlation of CD4−CD8−T cells with the EBV infection. Multivariate analysis showed that hampered recovery of CD4−CD8−T cells and EBV reactivation were the independent risk factors to predict transplant-related mortality. Our findings may facilitate the intervention strategies to improve the overall survival of haploHSCT recipients.
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This study is supported by Key Program of the National Natural Science Foundation of China (Grant No 81230013) and National Natural Science Foundation of China (Grant No. 81370666).
The authors declare no conflict of interest.
About this article
Incidence, risk factors, and clinical significance of Epstein–Barr virus reactivation in myelodysplastic syndrome after allogeneic haematopoietic stem cell transplantation
Annals of Hematology (2019)
Bone Marrow Transplantation (2019)
Blood Reviews (2019)
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