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Bone marrow aspiration technique has deteriorated in recent years

Bone Marrow Transplantation volume 50, pages 1007–1009 (2015)Cite this article

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HSCT is a potentially curative treatment for many haematological malignancies and some non-malignant disorders.1, 2, 3 In the early days of HSCT bone marrow (BM) was the only source of hematopoietic stem cells. However, during the last two decades a shift has occurred. Nowadays most transplant centres use more stem cells from peripheral blood (PBSC) than from BM.4, 5, 6 As a consequence aspiration of BM has become a rather rare event for many physicians, especially at smaller centres. To obtain a “good” stem-cell rich BM harvest, an experienced physician with good aspiration technique is of outmost importance. As the number of BM aspirations has decreased dramatically during the last decades the logical consequence is that the opportunity to obtain this experience has decreased considerably. It has been shown previously that the number of CD34+ cells transplanted with the bone marrow graft impacts engraftment rate, NRM and survival.7, 8, 9, 10 So we asked the question whether the quality of the BM grafts and CD34+ cell dose has deteriorated during recent years? Furthermore, we wanted to investigate if there is any difference in quality (measured as relative content of CD34+ cells) and CD34+ cell dose between BM grafts aspirated at our centre for our own patients and BM grafts acquired from another centre where no connection exists between physician and patient.

To answer the first question we analysed the relative content of CD34+ cells in BM grafts given to patients undergoing HSCT at our centre between 1995 and 2011. For the second question we compared BM harvests performed at our centre (sibling donors) with harvests performed at other centres (URD).

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Authors and Affiliations

  1. Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    M Remberger, O Ringdén & J Mattsson

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  1. M Remberger
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  2. O Ringdén
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  3. J Mattsson
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Correspondence to M Remberger.

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Remberger, M., Ringdén, O. & Mattsson, J. Bone marrow aspiration technique has deteriorated in recent years. Bone Marrow Transplant 50, 1007–1009 (2015). https://doi.org/10.1038/bmt.2015.75

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