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Plasmacytoid dendritic cells in allogeneic hematopoietic cell transplantation: benefit or burden?

Bone Marrow Transplantation volume 51, pages 333–343 (2016)Cite this article

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Abstract

Plasmacytoid dendritic cells (pDCs) bridge innate and adaptive immune responses and have important roles in hematopoietic engraftment, GvHD and graft-versus-leukemia responses following allogeneic hematopoietic cell transplantation (HCT). In addition, pDCs mediate antiviral immunity, particularly as they are the body’s primary cellular source of type I interferon. Given their pleiotropic roles, pDCs have emerged as cells that critically impact transplant outcomes, including overall survival. In this article, we will review the pre-clinical and clinical literature, supporting the crucial roles that pDCs assume as key immune effector cells during HCT.

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Acknowledgements

We wish to acknowledge the many valuable contributions of investigators whose work on plasmacytoid DCs was not included given the focus of the review and space limitations.

Author contributions

JJA: conception and design, primary writing of the manuscript; SMD and EKW reviewed and revised the manuscript.

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Authors and Affiliations

  1. Host Defense Program, Hematology/Oncology/Bone Marrow Transplant and Infectious Diseases, Nationwide Children’s Hospital, Columbus, OH, USA

    J J Auletta

  2. The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA

    J J Auletta & S M Devine

  3. Departments of Pediatrics and Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA

    J J Auletta

  4. Blood and Marrow Transplant Program, The James Cancer Hospital and Solove Research Institute, Columbus, OH, USA

    S M Devine

  5. Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA

    S M Devine

  6. Bone Marrow and Stem Cell Transplant Program, Winship Cancer Institute, Atlanta, GA, USA

    E K Waller

  7. Departments of Medicine, Pathology, and Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA

    E K Waller

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  1. J J Auletta
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Correspondence to J J Auletta.

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Auletta, J., Devine, S. & Waller, E. Plasmacytoid dendritic cells in allogeneic hematopoietic cell transplantation: benefit or burden?. Bone Marrow Transplant 51, 333–343 (2016). https://doi.org/10.1038/bmt.2015.301

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  • DOI: https://doi.org/10.1038/bmt.2015.301

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