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Pediatric Transplants

Long-term outcome of childhood aplastic anemia patients who underwent allogeneic hematopoietic SCT from an HLA-matched sibling donor in Japan

Bone Marrow Transplantation volume 48, pages 657–660 (2013)Cite this article

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Abstract

We report long-term outcomes of 329 childhood severe aplastic anemia (SAA) patients who underwent hematopoietic SCT (HSCT) from an HLA-matched sibling donor in the Japanese Hematopoietic Cell Transplantation Registry. OS and EFS at 10 years were as high as 89.7+/−1.7% and 85.5+/−2.0%, respectively. Five cases of late malignancies (LM) were identified (malignant peripheral nerve sheath tumor, thyroid carcinoma, colon carcinoma, MDS and hepatoblastoma). Cumulative incidence of LM was 0.8% at 10 years and 2.5% at 20 years, respectively, which was lower than that in previous reports. This low incidence is in keeping with the low occurrence of skin cancer in Japanese population and of acute GVHD in our study group. Radiation-containing conditioning was not significantly associated with the incidence of LM after HSCT probably because of absolute low patient number who developed LM in our series. In terms of LM development after HSCT, low-dose TBI in HSCT for SAA to avoid graft rejection, which is commonly used in Japan, might be tolerable in the Japanese population because of its low incidence.

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Acknowledgements

We thank all participating doctors and patients who were involved in the Japanese Hematopoietic Cell Transplantation Registry.

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Authors and Affiliations

  1. Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan

    A Kikuchi

  2. Department of Cell Transplantation and Regeneration Medicine, Tokai University School of Medicine, Isehara, Japan

    H Yabe

  3. Division of Pediatric Hematology/Oncology, Children's Medical Center Japanese Red Cross Nagoya First Hospital, Nagoya, Japan

    K Kato & N Yoshida

  4. Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan

    K Koh

  5. Section of Pediatrics, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan

    J Inagaki

  6. Department of Pediatrics, Tohoku University, Sendai, Japan

    Y Sasahara

  7. Department of Hemaopoietic Stem Cell Transplantation Data Management, Nagoya University School of Medicine, Nagoya, Japan

    R Suzuki

  8. Division of Hematology and Oncology, Shizuoka Children's Hospital, Shizuoka, Japan

    K Kudo

  9. Department of Pediatrics, Sapporo Hokuyuu Hospital, Sapporo, Japan

    R Kobayashi

  10. Department of Pediatrics, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan

    K Tabuchi

  11. Japanese Red Cross Osaka Blood Center, Osaka, Japan

    K Kawa

  12. Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan

    S Kojima

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  1. A Kikuchi
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  10. R Kobayashi
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for the Japanese Hematopoietic Cell Transplantation Registry

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Correspondence to A Kikuchi.

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Kikuchi, A., Yabe, H., Kato, K. et al. Long-term outcome of childhood aplastic anemia patients who underwent allogeneic hematopoietic SCT from an HLA-matched sibling donor in Japan. Bone Marrow Transplant 48, 657–660 (2013). https://doi.org/10.1038/bmt.2012.205

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