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Allografting

Long-term outcome of reduced-intensity allogeneic hematopoietic SCT in patients with AML in CR

Bone Marrow Transplantation volume 47, pages 212–216 (2012)Cite this article

Abstract

A total of 36 consecutive patients with AML in CR underwent reduced-intensity allogeneic hematopoietic SCT (RISCT) with fludarabine and melphalan conditioning. All patients were ineligible for myeloablative transplantation because of age or comorbidity. In total, 30 patients were in first CR and six patients were in second CR. Donors were siblings in 21 (58%) patients and were unrelated in 15 (42%) patients. Hematopoietic cell transplant specific comorbidity scores ⩾3 were present in 26 (72%) patients. With a median follow-up of 52 months (range, 34–103 months), OS and PFS rates at 4 years were 71% (s.e., 8%) and 68% (s.e., 8%), respectively. At 4 years, the cumulative incidence of non-relapse mortality was 20% (s.e., 7%) and of relapse mortality was 8% (s.e., 5%). Neither OS nor PFS was affected by older age (>60 years), unrelated donor, melphalan dose, or comorbidity score. At last follow up, of the 24 surviving patients, 21 (88%) had performance status (ECOG) of 0 without any active chronic GVHD requiring steroids. Hence, RISCT with fludarabine and melphalan conditioning produces durable long-term remission in older patients with AML.

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Authors and Affiliations

  1. Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    U Popat, M J de Lima, R M Saliba, P Anderlini, B S Andersson, A M Alousi, C Hosing, Y Nieto, S Parmar, I F Khouri, P Kebriaei, M Qazilbash & R E Champlin

  2. Department of Bone Marrow Transplant Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    S A Giralt

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  1. U Popat
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  2. M J de Lima
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  6. A M Alousi
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  7. C Hosing
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  14. S A Giralt
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Correspondence to U Popat.

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Competing interests

Richard Champlin has received consultant/advisory fees from Genzyme; and research funding from Otsuka and Genzyme. The remaining authors declare no competing financial interests.

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Popat, U., de Lima, M., Saliba, R. et al. Long-term outcome of reduced-intensity allogeneic hematopoietic SCT in patients with AML in CR. Bone Marrow Transplant 47, 212–216 (2012). https://doi.org/10.1038/bmt.2011.61

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  • DOI: https://doi.org/10.1038/bmt.2011.61

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