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Autografting

High-dose chemotherapy and auto-SCT in elderly patients with Hodgkin's lymphoma

Bone Marrow Transplantation volume 46, pages 1339–1344 (2011)Cite this article

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Abstract

Our purpose was to assess efficacy and toxicity of high-dose chemotherapy (HDCT) and ASCT in patients with relapsed and refractory Hodgkin's lymphoma (HL) aged 60 years and older and compare the results with a group of younger HL patients treated in a similar manner. We identified 15 consecutive patients, with HL aged 60 years and older who underwent HDCT (etoposide 60 mg/kg+ melphalan 160 mg/m2) and ASCT at our institution from May 2001 to March 2008. The results were compared with a cohort of 157 younger HL patients treated in a similar manner from January 1999 to December 2006. After a median follow-up of 2.5 years, PFS at 3 years after ASCT was 73% (95% confidence interval (CI) 37–90) for the older group and 56% (95% CI 46–64) for the younger group (P=0.45); OS after ASCT was 88% (95% CI 39–98) for the older group and 84% (95% CI 75–90) for the younger group (P=0.80). No transplant-related deaths were seen. Our study suggests that ASCT is feasible for selected elderly patients with HL, giving similar results to younger patients in terms of survival and toxicity.

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Authors and Affiliations

  1. Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Ontario, Canada

    N Puig, T Seshadri, K al-Farsi, N Franke, A Keating, J Kuruvilla & M Crump

  2. Autologous Blood and Marrow Transplant Service, Princess Margaret Hospital, Toronto, Ontario, Canada

    N Puig, T Seshadri, K al-Farsi, N Franke, A Keating, J Kuruvilla & M Crump

  3. Department of Biostatistics, Princess Margaret Hospital, Toronto, Ontario, Canada

    M Pintilie

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  1. N Puig
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Correspondence to M Crump.

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Puig, N., Pintilie, M., Seshadri, T. et al. High-dose chemotherapy and auto-SCT in elderly patients with Hodgkin's lymphoma. Bone Marrow Transplant 46, 1339–1344 (2011). https://doi.org/10.1038/bmt.2010.294

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  • DOI: https://doi.org/10.1038/bmt.2010.294

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