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SDF-1/CXCR4 blockade to mobilize hematopoietic progenitor cells from the placenta

Bone Marrow Transplantation volume 45, pages 1661–1662 (2010)Cite this article

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Umbilical cord blood has been introduced as an alternative graft source for allogeneic hematopoietic SCT in both pediatric and adult patients. However, the limited number of hematopoietic stem cells (HSC) leads to delayed engraftment, especially in adult recipients.1 Therefore, several groups are working on an optimized collection procedure in order to increase the number of transplantable progenitors. Bornstein et al.2 have demonstrated recently that a modified in utero/ex utero two-step collection procedure can lead to a significant increase in the number of harvested progenitor cells.

Especially in patients with a limited hematopoietic capacity, the bicyclam AMD3100, a CXCR4 antagonist, in combination with G-CSF is able to induce a significant mobilization of CD34+ cells.3 Dipersio et al. have already shown that AMD3100 may provide an alternative method of HSC mobilization even in allogeneic donors.4 Gene expression data indicate that AMD3100-mobilized HSCs may represent a functionally different subset of HSCs.5

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Acknowledgements

This work was sponsored by DFG grant ‘Collaborative Research Center 655’: Cells into tissues: stem cell and progenitor commitment and interactions during tissue formation (SFB 655, Dresden).

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  1. D Jing and N Alakel: These authors contributed equally to this work.

Authors and Affiliations

  1. Medical Clinic and Policlinic I, University Hospital, Dresden, Germany

    D Jing, N Alakel, M Bornhäuser, G Ehninger & R Ordemann

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  1. D Jing
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  2. N Alakel
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  3. M Bornhäuser
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  4. G Ehninger
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  5. R Ordemann
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Correspondence to R Ordemann.

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Jing, D., Alakel, N., Bornhäuser, M. et al. SDF-1/CXCR4 blockade to mobilize hematopoietic progenitor cells from the placenta. Bone Marrow Transplant 45, 1661–1662 (2010). https://doi.org/10.1038/bmt.2010.22

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