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Disappointing outcome of allogeneic hematopoietic SCT in two EATL patients

Bone Marrow Transplantation volume 45, pages 959–960 (2010)Cite this article

Enteropathy-associated T-cell lymphoma (EATL) is associated with refractory celiac disease (RCD).1, 2 Approximately, 50% of patients with CD are diagnosed in adulthood; of them, 2–5% develop RCD. RCD patients comprise two groups: one with immunophenotypically aberrant intraepithelial lymphocytes (RCDII) and one without these cells (RCDI), the cutoff being 20%.2 Aberrant intraepithelial lymphocytes are characterized by the lack of surface expression of CD3 and often also CD8. Overall, 60–80% of RCDII patients develop EATL within 5 years.3

Enteropathy-associated T-cell lymphoma is almost invariably lethal, although high-dose chemotherapy followed by Auto-SCT might improve survival.3 Experience with myeloablative or reduced-intensity conditioned (RIC) Allo-SCT in T-cell non-Hodgkin's lymphoma is limited, but promising.4 We report the first two celiac patients with EATL in whom we performed Allo-RIC-SCT from an HLA-identical sibling donor.

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Authors and Affiliations

  1. Department of Haematology, VU University Medical Center, Amsterdam, The Netherlands

    J C Regelink, P C Huijgens, J J W M Janssen & O Visser

  2. Department of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, The Netherlands

    G J Tack & C J J Mulder

Authors
  1. G J Tack
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  2. P C Huijgens
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  3. C J J Mulder
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  4. J J W M Janssen
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  5. O Visser
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Correspondence to J C Regelink.

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The authors declare no conflict of interest.

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Regelink, J., Tack, G., Huijgens, P. et al. Disappointing outcome of allogeneic hematopoietic SCT in two EATL patients. Bone Marrow Transplant 45, 959–960 (2010). https://doi.org/10.1038/bmt.2009.250

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