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Isolated testicular relapse after allo-SCT in boys with ALL: outcome without second transplant

Bone Marrow Transplantation volume 45, pages 397–399 (2010)Cite this article

Isolated testicular relapse (ITR) of ALL after allo-SCT is an uncommon event and a significant management dilemma. Case reports of therapy for ITR post-SCT are few, and therapeutic options range from palliation to second transplantation (see online Supplementary Table 1). Here we report the largest series to date of seven boys with ITR post-SCT, treated at a single institution with systemic chemotherapy and without a second SCT. Five of the seven boys remain in remission. BM samples for two boys were available during the entire course of their disease for comparison of minimal residual disease (MRD) before and after SCT.

A retrospective review of the management and outcomes of boys with ITR post-SCT identified from the Sydney Children's Hospital (SCH) database from 1979 to 2008 was undertaken. MRD analysis was performed on BM using real-time quantitative PCR detection of patient-specific rearrangements of Ig heavy and kappa chain genes and T-cell receptor delta and gamma genes according to established methods.1

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Acknowledgements

This research was supported through grants from the NH&MRC and the Cancer Council of NSW. Standardisation and quality control of MRD testing was supported by the ESG-MRD-ALL. VB received a Fellowship from the Steven Walter Foundation. Children's Cancer Institute Australia for Medical Research is affiliated with the University of New South Wales and Sydney Children's Hospital.

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Authors and Affiliations

  1. Centre for Children's Cancer and Blood Disorders, Sydney Children's Hospital, Sydney, Australia

    V A Bhadri, M R McGregor, S J Russell & G M Marshall

  2. Children's Cancer Institute Australia for Medical Research, Sydney, Australia

    N C Venn, N Hackenberg, M D Norris, M Haber, R Sutton & G M Marshall

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  1. V A Bhadri
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  2. M R McGregor
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  3. N C Venn
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  4. N Hackenberg
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  5. S J Russell
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  6. M D Norris
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  7. M Haber
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  8. R Sutton
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  9. G M Marshall
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Correspondence to G M Marshall.

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Bhadri, V., McGregor, M., Venn, N. et al. Isolated testicular relapse after allo-SCT in boys with ALL: outcome without second transplant. Bone Marrow Transplant 45, 397–399 (2010). https://doi.org/10.1038/bmt.2009.138

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