Abstract
This retrospective study was conducted to evaluate the safety and complications profile of general anaesthesia (GA) compared with that of regional anaesthesia (RA) for BM harvesting (BMH). The study included 281 donations carried out between 1992 and 1999. Of these, 204 (73%) were allogeneic donations, and GA was carried out in 69% (140 of 204) and RA in 31% (64 of 204) of cases. The other 77 donations were autologous (27%), using GA in 87% (67 of 77) and RA in 13% (10 of 77) of cases. No life-threatening complications occurred, but there were minor intra- and postoperative events during 26 (9%) and after 58 (21%) donations. Postoperative nausea and vomiting was reported in 40 (14%) cases and post-spinal headache after five out of 58 (8.6%) donations in which spinal anaesthesia was carried out. The incidence of intra- and postoperative events did not differ significantly between the GA and RA groups. However, the incidence of postoperative events was higher in the allogeneic group compared with that in the autologous group (25 vs 10%, P<0.01) and in female donors compared with male donors (29 vs 14%, P=0.002). In conclusion, both GA and RA are comparable with regard to BMH. Nevertheless, non-severe intra- and postoperative events were frequent.
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References
Buckner CD, Clift RA, Sanders JE, Stewart P, Bensinger WI, Doney KC et al. Marrow harvesting from normal donors. Blood 1984; 64: 630–634.
Bortin MM, Buckner CD . Major complications of marrow harvesting for transplantation. Exp Hematol 1983; 11: 916–921.
Stroncek DF, Holland PV, Bartch G, Bixby T, Simmons RG, Antin JH et al. Experiences of the first 493 unrelated marrow donors in the National Marrow Donor Program. Blood 1993; 81: 1940–1946.
Lavi A, Efrat R, Feigin E, Kadari A . Regional versus general anesthesia for bone marrow harvesting. J Clin Anesth 1993; 5: 204–206.
Knudsen LM, Johnsen HE, Gaarsdal E, Jensen L . Spinal versus general anaesthesia for bone marrow harvesting (letter). Bone Marrow Transplant 1995; 15: 486–487.
Burmeister MA, Standl T, Brauer P, Ramsperger K, Kroger N, Zander A et al. Safety and efficacy of spinal vs general anaesthesia in bone marrow harvesting. Bone Marrow Transplant 1998; 21: 1145–1148.
Mingus ML . Recovery advantages of regional anesthesia compared with general anesthesia: adult patients. J Clin Anesth 1995; 7: 628–633.
Gulur P, Nishimori M, Ballantyne JC . Regional anaesthesia versus general anaesthesia, morbidity and mortality. Best Practice Res Clin Anaesth 2006; 20: 249–263.
Rasmussen LS, Johnson T, Kuipers HM, Kristensen D, Siersma VD, Vila P et al. Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol Scand 2003; 47: 260–266.
Salonia A, Crescenti A, Suardi N, Memmo A, Naspro R, Bocciardi AM et al. General versus spinal anesthesia in patients undergoing radical retropubic prostatectomy: results of a prospective, randomized study. Urology 2004; 64: 95–100.
Schuricht AL, McCarthy CS, Wells WL, Kumor RJ, Cwik J . A comparison of epidural versus general anesthesia for outpatient endoscopic preperitoneal herniorrhaphy. JSLS 1997; 1: 141–144.
Urwin SC, Parker MJ, Griffiths R . General versus regional anaesthesia for hip fracture surgery: a meta-analysis of randomized trials. Br J Anaesth 2000; 84: 450–455.
Jellish WS, Thalji Z, Stevenson K, Shea J . A prospective randomized study comparing short- and intermediate-term perioperative outcome variables after spinal or general anesthesia for lumbar disk and laminectomy surgery. Anesth Analg 1996; 83: 559–564.
McLain RF, Kalfas I, Bell GR, Tetzlaff JE, Yoon HJ, Rana M . Comparison of spinal and general anesthesia in lumbar laminectomy surgery: a case-controlled analysis of 400 patients. J Neurosurg Spine 2005; 2: 17–22.
Filshie J, Pollock AN, Hughes RG, Omar YA . The anaesthetic management of bone marrow harvest for transplantation. Anaesthesia 1984; 39: 480–484.
Heldal D, Brinch L, Tjonnfjord G, Solheim BG, Egeland T, Gadeholt G et al. Donation of stem cells from blood or bone marrow: results of a randomised study of safety and complaints. Bone Marrow Transplant 2002; 29: 479–486.
Gandini A, Roata C, Franchini M, Agostini E, Guizzardi E, Pontiero Giacometti P et al. Unrelated allogeneic bone marrow donation: short- and long-term follow-up of 103 consecutive volunteer donors. Bone Marrow Transplant 2001; 28: 369–374.
Jin NR, Hill RS, Petersen FB, Buckner CD, Stewart PS, Amos D et al. Marrow harvesting for autologous marrow transplantation. Exp Hematol 1985; 13: 879–884.
Weir I, Holmes HI, Young ER . Venous sequelae following venipuncture and intravenous diazepam administration. Part one: etiological factors. Oral Health 1996; 86: 9–17.
Weir I, Holmes HI, Young ER . Venous Sequelae. Part 2: other influencing factors and techniques for dealing with the problem. Oral Health 1996; 87: 31–38.
Tammela T . Postoperative urinary retention—why the patient cannot void. Scand J Urol Nephrol 1995; 29 (Suppl 175): 75–77.
Keita H, Diouf E, Tubach F, Brouwer T, Dahmani S, Mantz J et al. Predictive factors of early postoperative urinary retention in the post anesthesia care unit. Anesth Analg 2005; 101: 592–596.
Acknowledgements
We thank the nursing staff at the Departments of Anaesthesiology, Haematology and Transplantation surgery for their excellent patient care and Ms Hanna Svensson for statistical advice.
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Machaczka, M., Kalaitzakis, E., Eleborg, L. et al. Comparison of general vs regional anaesthesia for BM harvesting: a retrospective study of anaesthesia-related complications. Bone Marrow Transplant 45, 53–61 (2010). https://doi.org/10.1038/bmt.2009.109
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DOI: https://doi.org/10.1038/bmt.2009.109
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