Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Comparable engraftment and chimerism kinetics using oral and intravenous fludarabine as part of a reduced intensity conditioning regimen

Bone Marrow Transplantation volume 42, pages 137–138 (2008)Cite this article

Allogeneic stem cell transplantation is a potentially curative treatment for patients with hematological malignancies. Traditionally, myeloablative conditioning regimens have been used that induce considerable toxicity, limiting the procedure to younger patients. To provide the curative potential of allo-SCT to patients of higher age or with concomitant disease, RIC regimens have been developed.1 Due to the nonmyeloablative nature of these regimens, most patients are mixed chimeras after allo-SCT with both donor and residual patient hematopoiesis present.

Intravenous fludarabine is used in many RIC protocols, combined with either low-dose TBI or different combinations of cyclophosphamide, busulfan, melphalan or antithymocyte globulin.1 An oral formulation of fludarabine has become available, which, however, was reported to have a large interindividual variation in systemic bioavailability of 30–80%.2 The use of oral fludarabine may, therefore, potentially affect engraftment or may result in diminished donor hematopoiesis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Giralt S . Reduced-intensity conditioning regimens for hematologic malignancies: what have we learned over the last 10 years? Hematology Am Soc Hematol Educ Program 2005, 384–389.

  2. Foran JM, Oscier D, Orchard J, Johnson SA, Tighe M, Cullen MH et al. Pharmacokinetic study of single doses of oral fludarabine phosphate in patients with ‘low-grade’ non-Hodgkin's lymphoma and B-cell chronic lymphocytic leukemia. J Clin Oncol 1999; 17: 1574–1579.

    Article  CAS  Google Scholar 

  3. Barge RM, Osanto S, Marijt WA, Starrenburg CW, Fibbe WE, Nortier JW et al. Minimal GVHD following in-vitro T cell-depleted allogeneic stem cell transplantation with reduced-intensity conditioning allowing subsequent infusions of donor lymphocytes in patients with hematological malignancies and solid tumors. Exp Hematol 2003; 31: 865–872.

    Article  CAS  Google Scholar 

  4. Subirà M, Sureda A, Ancín I, Martino R, Altés A, Brunet S et al. Allogeneic stem cell transplantation with reduced-intensity conditioning is potentially feasible as an outpatient procedure. Bone Marrow Transplant 2003; 32: 869–872.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands. E-mail: P.A.von_dem_Borne@lumc.nl,

    P A von dem Borne, C W Starrenburg, R M Barge, E W Marijt, J H F Falkenburg & R Willemze

Authors
  1. P A von dem Borne
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C W Starrenburg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R M Barge
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E W Marijt
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J H F Falkenburg
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R Willemze
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

von dem Borne, P., Starrenburg, C., Barge, R. et al. Comparable engraftment and chimerism kinetics using oral and intravenous fludarabine as part of a reduced intensity conditioning regimen. Bone Marrow Transplant 42, 137–138 (2008). https://doi.org/10.1038/bmt.2008.96

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2008.96

This article is cited by

Search

Advanced search

Quick links