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Segregated graft-versus-tumor effect between CNS and non-CNS lesions of Ewing's sarcoma family of tumors

Bone Marrow Transplantation volume 41, pages 1067–1068 (2008)Cite this article

For patients with the localized Ewing's sarcoma family of tumors (ESFT), first-line multimodal treatment, including intensive multi-agent chemotherapy, local radiation therapy and surgery, produces 70–75% of the long-term survival rate.1, 2 However, once patients relapse, there is no effective treatment that yields a 5-year survival rate exceeding 20%, even with high-dose chemotherapy (HDC) with autologous stem cell rescue.3, 4 Therefore, a new and more effective treatment approach is clearly needed for this population. Several reports have described patients with ESFT who had bone marrow metastases and underwent allogeneic SCT instead of autologous SCT,5 including a rare patient who exhibited evidence of a graft-versus-tumor (GVT) effect.6 To accumulate further knowledge, we report the case of a patient with recurrent ESFT who responded to allogeneic SCT from a sibling donor. A unique aspect of this case was that the manifestation of the GVT effect differed in different organs, with involvement of central nervous system (CNS) and non-CNS lesions. The GVT effect is rare in CNS diseases.

In this case, we followed the patient mainly by CT scanning. Although the CT findings showed the tumor status fairly well, they could not provide information regarding viability of the residual tumor. In this regard, PET scanning would be very helpful.

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References

  1. Marina NM, Pappo AS, Parham DM, Cain AM, Rao BN, Poquette CA et al. Chemotherapy dose-intensification for pediatric patients with Ewing's family of tumors and desmoplastic small round cell tumor: a feasibility study at St Jude Children's Research Hospital. J Clin Oncol 1999; 17: 180–190.

    Article  CAS  PubMed  Google Scholar 

  2. Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003; 348: 694–701.

    Article  CAS  PubMed  Google Scholar 

  3. Barker LM, Pendergrass TW, Sanders JE, Hawkins DS . Survival after recurrence of Ewing's sarcoma family of tumors. J Clin Oncol 2005; 23: 4354–4362.

    Article  PubMed  Google Scholar 

  4. Galindo CR, Billups CA, Kun LE, Rao BN, Pratt CB, Merchant TE et al. Survival after recurrence of Ewing tumors. Cancer 2002; 94: 561–569.

    Article  Google Scholar 

  5. Burdach S, Kaick BV, Laws HJ, Ahrens S, Haase R, Korholz D et al. Allogenic and autologous stem-cell transplantation in advanced Ewing tumors. Ann Oncol 2000; 11: 1451–1462.

    Article  CAS  PubMed  Google Scholar 

  6. Koscielniak E, Wieltsch U, Treuner J, Winker P . Graft-versus-Ewing sarcoma effect and long-term remission induced by haploidentical stem-cell transplantation in a patient with relapse of metastatic disease. J Clin Oncol 2005; 23: 242–248.

    Article  PubMed  Google Scholar 

  7. Carson CM, Sutcliffe JG . Balancing function vs. self-defense: the CNS as an active regulator of immune response. J Neurosci Res 1999; 55: 1–8.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan

    A Hosono & A Makimoto

  2. Division of Orthopedic Surgery, National Cancer Center Hospital, Tokyo, Japan

    A Kawai

  3. Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan

    Y Takaue

Authors
  1. A Hosono
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  2. A Makimoto
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  3. A Kawai
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  4. Y Takaue
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Correspondence to A Hosono.

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Hosono, A., Makimoto, A., Kawai, A. et al. Segregated graft-versus-tumor effect between CNS and non-CNS lesions of Ewing's sarcoma family of tumors. Bone Marrow Transplant 41, 1067–1068 (2008). https://doi.org/10.1038/bmt.2008.26

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