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Treatment of adult AML with t(6;11)(q27;q23) by allogeneic hematopoietic SCT in the first CR

Bone Marrow Transplantation volume 42, pages 553–554 (2008)Cite this article

AML with t(6;11)(q27;q23) is the most prognostically unfavorable subset of AML with 11q23 abnormalities,1 with an estimated 2-year survival of 13%2 and a median overall survival (OS) period of 12 months.3 There have been no previous reports regarding the efficacy of allogeneic hematopoietic SCT (Allo-HSCT) in adult AML with t(6;11)(q27;q23) in the first CR. In this study, we performed a retrospective analysis of data from nine adult AML patients with t(6;11)(q27;q23) aged <60 years in the first CR to clarify the effects of Allo-HSCT in adult AML with this chromosomal abnormality in the first CR.

Data from nine adult (⩾17 years old) AML patients with t(6;11)(q27;q23) aged <60 years, diagnosed between 1990 and 2006 at six institutions in Japan, were included in the retrospective analysis. Chromosomal analysis was performed after culturing BM cells for 24–48 h. Twenty metaphase cells were analyzed after trypsin-Giemsa banding.

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References

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Authors and Affiliations

  1. Department of Hematology, Nippon Medical School, Tokyo, Japan

    H Tamai, H Yamaguchi, K Tajika, K Inokuchi & K Dan

  2. Department of Hematology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    S Takahashi & A Tojo

  3. Department of Hematology, Musashino Red Cross Hospital, Tokyo, Japan

    H Hamaguchi

  4. Department of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan

    T Kobayashi, H Akiyama & H Sakamaki

  5. Department of Hematology, Kanazawa University, Ishikawa, Japan

    H Okumura & Si Nakao

  6. Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan

    A Arai & O Miura

Authors
  1. H Tamai
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  2. H Yamaguchi
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  3. S Takahashi
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  4. A Tojo
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  5. H Hamaguchi
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  6. T Kobayashi
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  7. H Akiyama
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  8. H Sakamaki
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  9. H Okumura
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  10. Si Nakao
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  11. A Arai
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  12. O Miura
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  13. K Tajika
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  14. K Inokuchi
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  15. K Dan
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Correspondence to H Tamai.

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Tamai, H., Yamaguchi, H., Takahashi, S. et al. Treatment of adult AML with t(6;11)(q27;q23) by allogeneic hematopoietic SCT in the first CR. Bone Marrow Transplant 42, 553–554 (2008). https://doi.org/10.1038/bmt.2008.200

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