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Allogeneic hematopoietic stem cell transplantation in Tunisia

Bone Marrow Transplantation volume 42, pages S139–S141 (2008)Cite this article

Abstract

In 1998, the Tunisian team of the ‘Centre National de Greffe de Moelle Osseuse’ initiated allogeneic hematopoietic SCT (AHSCT) in Tunisia. As of June 2007, information was collected about 299 patients with a first AHSCT and 12 additional retransplants. The median age was 19 years (range 2–49 years). The main indications were aplastic anemia (n=106, 36%), leukemia and nonmalignant disorders (n=153, 51%), Fanconi anemia (n=26, 9%) and other nonmalignant disorders (n=14, 4%). Preparative regimens depended on indication. All donors were HLA geno-identical. The stem cell sources were BM (87%) and PBSCs (13%). At the time of analysis, 200 patients (67%) were alive after a median follow-up of 42 months (range 3–112 months). The overall TRM rate was 17%. Outcome depended on indication. According to our results, allogeneic HSCT is potentially curative for hematological diseases, but it is a toxic approach for malignant disorders.

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Authors and Affiliations

  1. Hematology Department, Centre National de Greffe de Moelle Osseuse de Tunis, Tunis, Tunisia

    T Ben Othman, L Torjemane, A Abdelkefi, A Lakhal, S Ladeb & A Ben Abdeladhim

  2. Centre National de Transfusion Sanguine de Tunis, Tunis, Tunisia

    L Ben Hamed & H Slama

Authors
  1. T Ben Othman
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  2. L Torjemane
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  3. A Abdelkefi
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  4. A Lakhal
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  5. S Ladeb
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  6. L Ben Hamed
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  7. H Slama
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  8. A Ben Abdeladhim
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Correspondence to T Ben Othman.

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Ben Othman, T., Torjemane, L., Abdelkefi, A. et al. Allogeneic hematopoietic stem cell transplantation in Tunisia. Bone Marrow Transplant 42 (Suppl 1), S139–S141 (2008). https://doi.org/10.1038/bmt.2008.143

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