Pharmacokinetics

Organic anion transporting polypeptide-1B1 haplotypes in Chinese patients

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Abstract

Aim:

To detect 388G>A and 521T>C variant alleles in the organic anion transporting polypeptide-1B1 (OATP1B1, encoding gene SLCO1B1) gene.

Methods:

One hundred and eleven healthy volunteers were screened for OATP1B1 alleles in our study. PCR-restriction fragment length polymorphism was used to identify the 388G>A polymorphism and a 1-step tetra-primer method was developed for the determination of 521T>C mutation.

Results:

The frequencies of the 388G>A and 521T>C variant alleles in the Chinese population were 73.4% and 14.0%, respectively. The frequencies of the SLCO1B1*1b and *15 haplotypes were 59.9% and 14.0%, respectively.

Conclusion:

The SLCO1B1*1b and SLCO1B1*15 variants are relatively common in the Chinese population. Their frequencies are similar to that in the Japanese, but significantly different from that in Caucasians and blacks.

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Author information

Correspondence to Hong-hao Zhou or Zhen-qiu Sun.

Additional information

Project supported by grants from the National Natural Science Foundation of China (No F30130210, C30000211, and C30200346) and the China Medical Board of New York (No 99-697 and 01-755)

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Keywords

  • organic anion transporting polypeptide-1B1
  • 388G>A
  • 521T>C
  • genotyping
  • Chinese patients

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