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  • Original Article
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Influence of environmental zinc on the association between environmental and biological measures of lead in children

Journal of Exposure Science & Environmental Epidemiology volume 13, pages 318–323 (2003)Cite this article

Abstract

Exposure to lead, a common environmental contaminant found at hazardous waste sites, has been associated with adverse health effects to humans. Zinc, a nutritionally essential metal, may influence both the absorption and the toxicity of lead. The purpose of this study was to determine if zinc levels present in the environment affect the association between environmental lead measured in two small communities in the northeastern United States and biological measurements of lead in the residents of these communities. Soil and dust sampled in and around the homes of all participants were tested for lead and zinc. Residents aged 6 months to 14 years (n=214) provided blood samples for the determination of blood lead concentrations. Soil and dust measurements of environmental lead were positively associated with blood lead, regardless of the corresponding zinc levels in these samples. However, the magnitude of this association was 20% to 46% lower in areas with high environmental measures of zinc. The interactions between environmental lead and environmental zinc levels and blood lead concentrations suggest that zinc may influence the association between soil and dust lead and corresponding blood lead levels.

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Acknowledgements

We thank Drs. James Logue and James Fox, Pennsylvania Department of Health for their contributions to the initial study of these communities. Drs. Robert Amler and Jeffrey A. Lybarger with the ATSDR and Drs. Michael McGeehin and Gina Terracciano, formerly with the ATSDR, provided leadership on the larger study from which the data was derived for the present analysis. We also thank Drs. Dave Campagna and Olivia Harris, ATSDR, for their thoughtful review.

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  1. Division of Health Studies, Agency for Toxic Substances and Disease Registry, Health Investigations Branch, Atlanta, 30333, Georgia, USA

    Curtis W Noonan, Steven J Kathman, Sara M Sarasua & Mary C White

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  1. Curtis W Noonan
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  2. Steven J Kathman
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  3. Sara M Sarasua
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Correspondence to Curtis W Noonan.

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Noonan, C., Kathman, S., Sarasua, S. et al. Influence of environmental zinc on the association between environmental and biological measures of lead in children. J Expo Sci Environ Epidemiol 13, 318–323 (2003). https://doi.org/10.1038/sj.jea.7500286

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