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Validation of a noninvasive neonatal optical cerebral oximeter in veno-venous ECMO patients with a cephalad catheter

Journal of Perinatology volume 26, pages 628–635 (2006)Cite this article

Abstract

Introduction:

Cerebral Oximetry is an optical technique that allows for noninvasive and continuous monitoring of brain oxygenation by determining tissue oxygen saturation (SctO2). In conjunction with pulse oximetry, cerebral oximetry offers a promising method to estimate cerebral venous oxygen saturation (SvO2).

Objective:

The aim of this study was to validate the cerebral oximetry measurements with the cerebral oxygen saturation measured from blood drawn in neonates on veno-venous ECMO with existing cephalad catheter with a prototype neonatal cerebral oximeter developed by CAS Medical Systems (Branford, CT, USA).

Study design:

After obtaining informed consent, neonates undergoing VV-ECMO with cephalad catheterization were monitored by the CAS cerebral oximeter. Cephalad blood samples were periodically obtained to validate the monitor's accuracy.

Results:

Seventeen neonates were studied with 1718 h of cerebral oximetry data collected. Compared to the reference values, the bias±precision for cerebral oximetry SctO2 was 0.4±5.1% and derived SvO2 was 0.6±7.3%

Conclusion:

We recommend the use of this noninvasive method as an alternative to blood draws for cerebral venous saturation measurements in neonates requiring extracorporeal life support.

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Abbreviations

ECMO:

extracorporeal membrane oxygenation

ELSO:

extracorporeal life support organization

VV:

veno-venous

VA:

veno-arterial

NIRS:

near infrared spectroscopy

SvO2:

cerebral venous oxygen saturation

SctO2:

cerebral tissue oxygen saturation

SpO2:

pulse oximeter arterial oxygen saturation

SaO2:

arterial oxygen saturation

SjvO2:

cephalad catheter internal jugular oxygen saturation

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Acknowledgements

Presented in part at the American Pediatric Society, Society of Pediatrics Research, San Francisco, CA. May 2004 and the American Academy of Pediatrics National Conference & Exhibition, San Francisco, CA. October 2004. The Study was supported by NIH NINDS Grant # R44NS39723 and sponsored by CAS Medical Systems.

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Authors and Affiliations

  1. Department of Neonatology, Children's National Medical Center, Washington, DC, USA

    K Rais-Bahrami & B L Short

  2. The George Washington University School of Medicine, Washington, DC, USA

    K Rais-Bahrami, O Rivera & B L Short

  3. Department of Biomedical Engineering, Children's National Medical Center, Washington, DC, USA

    O Rivera

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  1. K Rais-Bahrami
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Correspondence to K Rais-Bahrami.

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Rais-Bahrami, K., Rivera, O. & Short, B. Validation of a noninvasive neonatal optical cerebral oximeter in veno-venous ECMO patients with a cephalad catheter. J Perinatol 26, 628–635 (2006). https://doi.org/10.1038/sj.jp.7211573

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