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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Indomethacin-associated neutropenia with subsequent Gram-negative sepsis in a preterm infant. Cause or coincidence?

Journal of Perinatology volume 26, pages 381–383 (2006)Cite this article

Abstract

A preterm male infant with a patent ductus arteriosus developed neutropenia during treatment with indomethacin. Afterward, the mother described her own history of indomethacin-associated neutropenia. During the recovery from the neutropenia, the infant became septic with bacteremia caused by Enterobacter cloacae. Although indomethacin-related neutropenia has been described in adults, no case in a neonate has been reported. If neutropenia occurs after indomethacin therapy in a neonate, a familial history of indomethacin-associated neutropenia should be sought and the increased risk of infection should be considered.

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Author information

Author notes

  1. B-O S Bengtsson

    Present address: Pediatrix Medical Group of California, Ventura, CA, USA

  2. M P Sherman

    Present address: Southern Illinois University School of Medicine, Springfield, IL, USA

Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, University of California, Davis, CA, USA

    B-O S Bengtsson, J M Milstein & M P Sherman

Authors
  1. B-O S Bengtsson
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  2. J M Milstein
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  3. M P Sherman
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Correspondence to M P Sherman.

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Bengtsson, BO., Milstein, J. & Sherman, M. Indomethacin-associated neutropenia with subsequent Gram-negative sepsis in a preterm infant. Cause or coincidence?. J Perinatol 26, 381–383 (2006). https://doi.org/10.1038/sj.jp.7211515

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  • DOI: https://doi.org/10.1038/sj.jp.7211515

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